ArticleJournal of the peripheral nervous system : JPNS2011
Outcome measures for Charcot-Marie-Tooth disease: clinical and neurofunctional assessment in children.
Article in Journal of the peripheral nervous system : JPNS, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
10 citing papers in PubMed, 20 citations in OpenAlex.
- Is gaitrite system sensitive in discriminating gait pattern of subjects affected by Charcot Marie tooth? A pilot study.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2025Article
- Foot Assessment Clinical Scales in Charcot-Marie-Tooth Patients: A Scoping Review.Frontiers in human neuroscience · 2022Article
- Walking and weakness in children: a narrative review of gait and functional ambulation in paediatric neuromuscular disease.Journal of foot and ankle research · 2020Review
- Mice with an autosomal dominant Charcot-Marie-Tooth type 2O disease mutation in both dynein alleles display severe moto-sensory phenotypes.Scientific reports · 2019Article
- Non-linear growth trends of toe flexor muscle strength among children, adolescents, and young adults: a cross-sectional study.European journal of applied physiology · 2018Article
- Natural history of Charcot-Marie-Tooth disease during childhood.Annals of neurology · 2017Article
- Nine-hole Peg Test and Ten-meter Walk Test for Evaluating Functional Loss in Chinese Charcot-Marie-Tooth Disease.Chinese medical journal · 2017Article
- Vincristine-induced peripheral neuropathy in pediatric cancer patients.American journal of cancer research · 2016Review
- Changes of gait pattern in children with Charcot-Marie-Tooth disease type 1A: a 18 months follow-up study.Journal of neuroengineering and rehabilitation · 2013Article
- Transitioning outcome measures: relationship between the CMTPedS and CMTNSv2 in children, adolescents, and young adults with Charcot-Marie-Tooth disease.Journal of the peripheral nervous system : JPNS · 2013Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
Abstract
Charcot-Marie-Tooth (CMT) disease is the most common inherited neuromuscular disorder, presenting with symptoms often occurring since childhood, and showing a progressive course. At present, there are no valid and reliable measures for evaluation of impairment and disability in the pediatric population. The aim of this study was to determine the usefulness of outcome measures, commonly used in adult patients, in CMT children. We report the results of a comprehensive evaluation of 21 children affected with CMT type 1A, including clinical examinations, measure of hand and foot muscle strength with a hand-held dynamometer, and the following scales: CMT Neuropathy Score or its clinical component CMT Examination Score, Overall Neuropathy Limitations Scale (ONLS), Walk-12 questionnaire, and nine-hole peg test (9-HPT). Hand grip, three-point pinch, and foot dorsiflexion strength were significantly lower than age/sex equivalent in almost all cases. 9-HPT was significantly abnormal in 62% of patients and CMT Examination Score was <10 points in all cases. ONLS showed presence of minor disability in the upper limbs in 57% and mild abnormalities of gait in 71% of patients. Overall, these scales demonstrated limited potential to measure disability and severity of the disease confirming that it is necessary to identify specific scales for children with CMT.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.