Evidence map›Paper›PMID 22003908›Full record

ReviewBiomarkers in medicine2011

Prospects for imaging-related biomarkers of human epileptogenesis: a critical review.

William A Gomes, Shlomo Shinnar

Open access · greenAbstract readReview
In one paragraph

Review in Biomarkers in medicine, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
2.4field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 25 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. The Epilepsy Spectrum: Targeting Future Research Challenges.Cold Spring Harbor perspectives in medicine · 2016
    Review
  7. Status Epilepticus.Cold Spring Harbor perspectives in medicine · 2016
    Review
  8. Update on Cysticercosis Epileptogenesis: the Role of the Hippocampus.Current neurology and neuroscience reports · 2016
    Review
  9. Review
  10. Neuroimaging the epileptogenic process.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2014
    Review
  11. Anti-epileptogenic clinical trial designs in epilepsy: issues and options.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2014
    Review
  12. Article
  13. Review
  14. Review
  15. Article
  16. Article
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

William A GomesComprehensive Epilepsy Management Center, Montefiore Medical Center, 111 E. 210th St, Bronx, NY 10467, USA.
Shlomo Shinnar
Montefiore Medical Center · US

Funding

Consequences of Prolonged Febrile Seizures in ChildhoodR01NS043209 · NINDS · MONTEFIORE MEDICAL CENTER (BRONX, NY) · PI SHINNAR, SHLOMO · 2003 to 2012
$21.5M
Consequences of Prolonged Febrile Seizures in ChildhoodR37NS043209 · NINDS · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI SHINNAR, SHLOMO · 2013 to 2019
$11.4M
NINDS NIH HHS NS 43209NINDS NIH HHS R01 NS043209NINDS NIH HHS R37 NS043209
6 · The paper itself

Abstract

To facilitate the study of epileptogenesis in humans, noninvasive biomarkers of epileptogenesis are required. No validated biomarker is currently available, but brain imaging techniques provide many attractive candidates. In this article we examine the imaging features of temporal lobe epilepsy, focusing on those that may precede the onset of epilepsy and correlate with epileptogenesis. Hippocampal volumetry and T(2) relaxometry are proposed as candidate biomarkers of epileptogenesis in temporal lobe epilepsy following febrile status epilepticus. Preliminary data suggest that these have promise, and the ongoing Consequences of Prolonged Febrile Seizures in Childhood (FEBSTAT) study will provide more conclusive evidence as to their validity. At this time there are no other clear candidates for imaging-related biomarkers of epileptogenesis in human studies.

Indexed as

BiomarkersEpilepsy, Temporal LobeHippocampusHumansMagnetic Resonance ImagingPositron-Emission TomographyRadiographySclerosisBiomarkers

Identifiers

PMID22003908
PMCPMC3235417
OpenAlexW2003312366

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.