ArticleBeilstein journal of nanotechnology2011
Characterization of protein adsorption onto FePt nanoparticles using dual-focus fluorescence correlation spectroscopy.
Article in Beilstein journal of nanotechnology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 128 citations in OpenAlex.
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- Light Extinction by Agglomerates of Gold Nanoparticles: A Plasmon Ruler for Sub-10 nm Interparticle Distances.Analytical chemistry · 2022Article
- Influence of the chirality of carbon nanodots on their interaction with proteins and cells.Nature communications · 2021Article
- Advanced Static and Dynamic Fluorescence Microscopy Techniques to Investigate Drug Delivery Systems.Pharmaceutics · 2021Review
- Protein nanoparticles in drug delivery: animal protein, plant proteins and protein cages, albumin nanoparticles.Journal of nanobiotechnology · 2021Review
- Understanding nanoparticle endocytosis to improve targeting strategies in nanomedicine.Chemical Society reviews · 2021Review
- Analysing the nanoparticle-protein corona for potential molecular target identification.Journal of controlled release : official journal of the Controlled Release Society · 2020Review
- Synthetic molecular recognition nanosensor paint for microalbuminuria.Nature communications · 2019Article
- Monitoring drug nanocarriers in human blood by near-infrared fluorescence correlation spectroscopy.Nature communications · 2018Article
- Engineering Proteins at Interfaces: From Complementary Characterization to Material Surfaces with Designed Functions.Angewandte Chemie (International ed. in English) · 2018Review
- An apolipoprotein-enriched biomolecular corona switches the cellular uptake mechanism and trafficking pathway of lipid nanoparticles.Nanoscale · 2017Article
- Synthesis and In Vitro Performance of Polypyrrole-Coated Iron-Platinum Nanoparticles for Photothermal Therapy and Photoacoustic Imaging.Nanoscale research letters · 2017Article
- Sensitive Analysis of Protein Adsorption to Colloidal Gold by Differential Centrifugal Sedimentation.Analytical chemistry · 2017Article
- Protein corona - from molecular adsorption to physiological complexity.Beilstein journal of nanotechnology · 2015Review
- Interaction of colloidal nanoparticles with their local environment: the (ionic) nanoenvironment around nanoparticles is different from bulk and determines the physico-chemical properties of the nanoparticles.Journal of the Royal Society, Interface · 2014Article
- Engineered nanoparticles interacting with cells: size matters.Journal of nanobiotechnology · 2014Review
- Effects of surface functionalization on the adsorption of human serum albumin onto nanoparticles - a fluorescence correlation spectroscopy study.Beilstein journal of nanotechnology · 2014Article
- PVP-coated, negatively charged silver nanoparticles: A multi-center study of their physicochemical characteristics, cell culture and in vivo experiments.Beilstein journal of nanotechnology · 2014Review
- In vitro interaction of colloidal nanoparticles with mammalian cells: What have we learned thus far?Beilstein journal of nanotechnology · 2014Review
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Using dual-focus fluorescence correlation spectroscopy, we have analyzed the adsorption of three human blood serum proteins, namely serum albumin, apolipoprotein A-I and apolipoprotein E4, onto polymer-coated, fluorescently labeled FePt nanoparticles (~12 nm diameter) carrying negatively charged carboxyl groups on their surface. For all three proteins, a step-wise increase in hydrodynamic radius with protein concentration was observed, strongly suggesting the formation of protein monolayers that enclose the nanoparticles. Consistent with this interpretation, the absolute increase in hydrodynamic radius can be correlated with the molecular shapes of the proteins known from X-ray crystallography and solution experiments, indicating that the proteins bind on the nanoparticles in specific orientations. The equilibrium dissociation coefficients, measuring the affinity of the proteins to the nanoparticles, were observed to differ by almost four orders of magnitude. These variations can be understood in terms of the electrostatic properties of the proteins. From structure-based calculations of the surface potentials, positively charged patches of different extents can be revealed, through which the proteins interact electrostatically with the negatively charged nanoparticle surfaces.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.