ArticleInternational journal of biochemistry and molecular biology2011
Regulation and function of the TAZ transcription co-activator.
Article in International journal of biochemistry and molecular biology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 33 citations in OpenAlex.
- Regulation of FGF-2, FGF-18 and Transcription Factor Activity by Perlecan in the Maturational Development of Transitional Rudiment and Growth Plate Cartilages and in the Maintenance of Permanent Cartilage Homeostasis.International journal of molecular sciences · 2022Review
- Biomaterials Regulate Mechanosensors YAP/TAZ in Stem Cell Growth and Differentiation.Tissue engineering and regenerative medicine · 2021Review
- The Role and Activation Mechanism of TAZ in Hierarchical Microgroove/Nanopore Topography-Mediated Regulation of Stem Cell Differentiation.International journal of nanomedicine · 2021Article
- Llgl1 regulates zebrafish cardiac development by mediating Yap stability in cardiomyocytes.Development (Cambridge, England) · 2020Article
- Transcriptional Coactivator TAZ Negatively Regulates Tumor Suppressor p53 Activity and Cellular Senescence.Cells · 2020Article
- High-fat and high-glucose microenvironment decreases Runx2 and TAZ expression and inhibits bone regeneration in the mouse.Journal of orthopaedic surgery and research · 2019Article
- Epigallocatechin-3-gallate affects the proliferation, apoptosis, migration and invasion of tongue squamous cell carcinoma through the hippo-TAZ signaling pathway.International journal of molecular medicine · 2018Article
- Multifaceted regulation and functions of YAP/TAZ in tumors (Review).Oncology reports · 2018Review
- MicroRNA-144 inhibits proliferation by targeting WW domain-containing transcription regulator protein 1 in papillary thyroid cancer.Oncology letters · 2018Article
- TAZ induces lung cancer stem cell properties and tumorigenesis by up-regulating ALDH1A1.Oncotarget · 2017Article
- Histone Deacetylase Inhibitors Target the Leukemic Microenvironment by Enhancing a Nherf1-Protein Phosphatase 1α-TAZ Signaling Pathway in Osteoblasts.The Journal of biological chemistry · 2015Article
- A role for the transducer of the Hippo pathway, TAZ, in the development of aggressive types of endometrial cancer.Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc · 2015Article
- RUNX2 and TAZ-dependent signaling pathways regulate soluble E-Cadherin levels and tumorsphere formation in breast cancer cells.Oncotarget · 2015Article
- Hippo Component TAZ Functions as a Co-repressor and Negatively Regulates ΔNp63 Transcription through TEA Domain (TEAD) Transcription Factor.The Journal of biological chemistry · 2015Article
- Inhibitory mechanism of FAT4 gene expression in response to actin dynamics during Src-induced carcinogenesis.PloS one · 2015Article
- WWTR1 (WW domain containing transcription regulator 1).Atlas of genetics and cytogenetics in oncology and haematology · 2014Article
- Polyomavirus small T antigen interacts with yes-associated protein to regulate cell survival and differentiation.Journal of virology · 2014Article
- Polarized and Stage-Dependent Distribution of Immunoreactivity for Novel PDZ-Binding Protein Preso1 in Adult Neurogenic Regions.Endocrinology and metabolism (Seoul, Korea) · 2014Article
- A Novel Cryptic t(2;3)(p21;q25) Translocation Fuses theCancer genomics & proteomicsArticle
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
TAZ (WWTR1), identified as a 14-3-3 binding protein with a PDZ binding motif, is implicated in mesenchymal stem cell differentiation. TAZ has been shown to be negatively regulated by phosphorylation-dependent and phosphorylation-independent mechanisms. Coupled with ASPP2, PP1 dephosphorylates TAZ to activate TAZ. TEADs mediate TAZ function in promoting cell proliferation and epithelial-mesenchymal transition (EMT). TAZ senses different cellular signals such as cell density and the extracellular matrix stiffness. Significantly, TAZ is overexpressed in breast cancer samples and papillary thyroid carcinoma tissues. These results indicate that TAZ plays an important role in cancer development and presents a novel target for TAZ overexpressed cancer therapy.
Indexed as
Identifiers
22003437PMC3193294W2291767161What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.