ReviewAddiction science & clinical practice2011
Neuronal mechanisms underlying development of nicotine dependence: implications for novel smoking-cessation treatments.
Review in Addiction science & clinical practice, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 74 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
74 citing papers in PubMed, 136 citations in OpenAlex.
- Co-action and changes in alcohol use during a smoking cessation attempt.Addiction (Abingdon, England) · 2024Trial
- Defining and predicting short-term alcohol use changes during a smoking cessation attempt.Addictive behaviors · 2015Trial
- Neuropharmacology of Nicotine Addiction and Therapeutic Strategies for Smoking Cessation.Biology · 2026Review
- Social Influences Across Vaping Trajectories of Female Tertiary Students.Drug and alcohol review · 2026Article
- E-cigarettes and periodontal health: current evidence and research gaps.Brazilian oral research · 2026Review
- Association between nicotine-dependent patients and delirium in intensive care units: a retrospective cohort study using a large clinical database.BMC psychiatry · 2025Article
- NICBrain sciences · 2025Article
- Voluntary nicotine consumption and reward in a subset of diversity outbred founder strains.Journal of psychopharmacology (Oxford, England) · 2024Article
- Cofilin linked to GluN2B subunits of NMDA receptors is required for behavioral sensitization by changing the dendritic spines of neurons in the caudate and putamen after repeated nicotine exposure.Behavioral and brain functions : BBF · 2024Article
- Greater ventral striatal functional connectivity in cigarette smokers relative to non-smokers across a spectrum of alcohol consumption.Brain imaging and behavior · 2024Article
- Impact of nicotine dependence on self-efficacy and readiness to quit among tobacco consumers in rural areas.Journal of family medicine and primary care · 2024Article
- New medications development for smoking cessation.Addiction neuroscience · 2023Article
- DISCOVERY AND VALIDATION OF GENES DRIVING DRUG-INTAKE AND RELATED BEHAVIORAL TRAITS IN MICE.bioRxiv : the preprint server for biology · 2023Article
- Nanoassemblies from the aqueous extract of roasted coffee beans modulate the behavioral and molecular effects of smoking withdrawal-induced anxiety in female rats.Drug delivery and translational research · 2023Article
- Altered functional dynamics gradient in schizophrenia with cigarette smoking.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Reward and inhibition in obesity and cigarette smoking: Neurobiological overlaps and clinical implications.Physiology & behavior · 2023Review
- Psychostimulant Misuse Among American Indian, Alaskan Native, or Native Hawaiian College Students in the U.S. From 2015 to 2019.Substance abuse : research and treatment · 2023Article
- Uncovering cloves: characterization of volatile compounds present in clove cigarettes.Toxicology research · 2022Article
- Effect of menthol on nicotine reduction: Pooled results from two double-blind randomized controlled trials.Brain research bulletin · 2022Review
- Neurotransmission Targets of Per- and Polyfluoroalkyl Substance Neurotoxicity: Mechanisms and Potential Implications for Adverse Neurological Outcomes.Chemical research in toxicology · 2022Review
14 more citing papers are in PubMed but not listed here.
Corrections and comments
- Commented on by
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Tobacco smoking causes high rates of mortality and morbidity throughout the world. Despite the availability of smoking-cessation medications, maintenance of long-term abstinence is difficult, and most individuals who attempt to quit smoking relapse. Although tobacco smoke contains many substances, researchers and policymakers agree that nicotine is a major cause of tobacco dependence. Understanding the neural substrates of nicotine dependence is essential for the development of more effective antismoking medications than those currently available. This article focuses on the neural substrates, especially nicotinic acetylcholine receptors, that mediate the reinforcing effects of nicotine and the development of nicotine dependence. Neuroadaptations in the function of the neurotransmitters dopamine, glutamate, and gamma-aminobutyric acid (GABA), which have been shown to be critically involved in nicotine dependence, are also reviewed. Finally, the article discusses progress in the discovery and development of smoking-cessation medications.
Indexed as
Identifiers
22003417PMC3188825W2164418506What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.