ReviewCurrent opinion in virology2011
From orphan virus to pathogen: the path to the clinical lab.
Review in Current opinion in virology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed, 30 citations in OpenAlex.
- Article
- Review
- Alternative applications for distinct RNA sequencing strategies.Briefings in bioinformatics · 2015Article
- The metagenomic approach and causality in virology.Revista de saude publica · 2015Article
- Diagnostic metagenomics: potential applications to bacterial, viral and parasitic infections.Parasitology · 2014Review
- Appearances can be deceptive: revealing a hidden viral infection with deep sequencing in a plant quarantine context.PloS one · 2014Article
- Rare and emerging viral infections in transplant recipients.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2013Review
- Nyamiviridae: proposal for a new family in the order Mononegavirales.Archives of virology · 2013Article
- Finding the lost treasures in exome sequencing data.Trends in genetics : TIG · 2013Review
- A roadmap to the human virome.PLoS pathogens · 2013Article
- Human parechovirus genotypes -10, -13 and -15 in Pakistani children with acute dehydrating gastroenteritis.PloS one · 2013Article
- Animal virus discovery: improving animal health, understanding zoonoses, and opportunities for vaccine development.Current opinion in virology · 2012Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Viral metagenomics has recently yielded numerous previously uncharacterized viral genomes from human and animal samples. We review some of the metagenomics tools and strategies to determine which orphan viruses are likely pathogens. Disease association studies compare viral prevalence in patients with unexplained symptoms versus healthy individuals but require these case and control groups to be closely matched epidemiologically. The development of an antibody response in convalescent serum can temporarily link symptoms with a recent infection. Neutralizing antibody detection require often difficult cell culture virus amplification. Antibody binding assays require proper antigen synthesis and positive control sera to set assay thresholds. High levels of viral genetic diversity within orphan viral groups, frequent co-infections, low or rare pathogenicity, and chronic virus shedding, can all complicate disease association studies. The limited availability of matched cases and controls sample sets from different age groups and geographic origins is a major block for estimating the pathogenic potential of recently characterized orphan viruses. Current limitations on the practical use of deep sequencing for viral diagnostics are listed.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.