Evidence map›Paper›PMID 22003377›Full record

ReviewCurrent opinion in virology2011

Viruses - from pathogens to vaccine carriers.

Juliana C Small, Hildegund C J Ertl

Open access · greenAbstract readReview
In one paragraph

Review in Current opinion in virology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed
2.8field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 47 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Article
  5. Article
  6. Review
  7. Review
  8. Nanocarrier vaccines for SARS-CoV-2.Advanced drug delivery reviews · 2021
    Article
  9. Review
  10. Article
  11. Review
  12. Review
  13. Vaccination against the Epstein-Barr virus.Cellular and molecular life sciences : CMLS · 2020
    Review
  14. Article
  15. Review
  16. Emerging viruses and current strategies for vaccine intervention.Clinical and experimental immunology · 2019
    Review
  17. Article
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Juliana C SmallUniversity of Pennsylvania Graduate Program, Philadelphia, PA, USA.
Hildegund C J Ertl
The Wistar Institute · USUniversity of Pennsylvania · US

Funding

Vector CoreU19AI074078 · NIAID · WISTAR INSTITUTE · PI ERTL, HILDEGUND C. J. · 2007 to 2012
$17.9M
Immune response to Adenoviral recombinants of ChimpanzeeP01AI052271 · NIAID · WISTAR INSTITUTE · PI ERTL, HILDEGUND C. J. · 2002 to 2006
$9.3M
Correlates of protection against SIV/SHIV challengeP01AI082282 · NIAID · WISTAR INSTITUTE · PI ERTL, HILDEGUND C. J. · 2009 to 2010
$5.6M
NIAID NIH HHS P01 AI052271NIAID NIH HHS P01 AI082282NIAID NIH HHS U19 AI074078
6 · The paper itself

Abstract

Vaccination is mankind's greatest public health success story. By now vaccines to many of the viruses that once caused fatal childhood diseases are routinely used throughout the world. Traditional methods of vaccine development through inactivation or attenuation of viruses have failed for some of the most deadly human pathogens, necessitating new approaches. Genetic modification of viruses not only allows for their attenuation but also for incorporation of sequences from other viruses, turning one pathogen into a vaccine carrier for another. Recombinant viruses have pros and cons as vaccine carriers, as discussed below using vectors based on adenovirus, herpesvirus, flavivirus, and rhabdovirus as examples.

Indexed as

AnimalsGenetic EngineeringGenetic VectorsHumansVaccinationVaccines, DNAViral VaccinesVirus DiseasesVirusesVaccines, DNAViral Vaccines

Identifiers

PMID22003377
PMCPMC3190199
OpenAlexW2068053683

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.