Evidence map›Paper›PMID 22003367›Full record

ArticleF1000 medicine reports2011

Anti-addiction vaccines.

Xiaoyun Shen, Frank M Orson, Thomas R Kosten

Abstract read
In one paragraph

Article in F1000 medicine reports, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Nicotine Replacement Therapy: An Overview.International journal of health sciences · 2016
    Review
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Xiaoyun Shen
Frank M Orson
Thomas R Kosten

Funding

Tiagabine and Disulfiram for Cocaine DependenceP50DA018197 · NIDA · YALE UNIVERSITY · PI OLIVETO, ALISON · 2004 to 2013
$12.6M
Development of Novel Vaccines for Cocaine AbuseR01DA030338 · NIDA · METHODIST HOSPITAL RESEARCH INSTITUTE · PI ORSON, FRANK M, WANG, RONGFU · 2010 to 2014
$1.6M
Vaccines for Sustainable Therapy of Opiate AddictionR01DA026859 · NIDA · BAYLOR COLLEGE OF MEDICINE · PI ORSON, FRANK M · 2009 to 2012
$1.4M
COMORBIDITY IN COCAINE AND OPIOID PHARMACOTHERAPYK05DA000454 · NIDA · YALE UNIVERSITY · PI KOSTEN, THOMAS RICHARD · 2000 to 2010
$1.3M
NIDA NIH HHS K05 DA000454NIDA NIH HHS P50 DA018197NIDA NIH HHS R01 DA026859NIDA NIH HHS R01 DA030338
6 · The paper itself

Abstract

Despite intensive efforts to eradicate it, addiction to both legal and illicit drugs continues to be a major worldwide medical and social problem. Anti-addiction vaccines can produce the antibodies to block the effects of these drugs on the brain, and have great potential to ameliorate the morbidity and mortality associated with illicit drug intoxications. This review provides a current overview of anti-addiction vaccines that are under clinical trial and pre-clinical research evaluation. It also outlines the development challenges, ethical concerns, and likely future intervention for anti-addiction vaccines.

Identifiers

PMID22003367
PMCPMC3186043

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.