SynthesisInvestigative ophthalmology & visual science2011
Complement factor D in age-related macular degeneration.
Synthesis in Investigative ophthalmology & visual science, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
49 citing papers in PubMed, 98 citations in OpenAlex.
- The effect of lutein supplementation on blood plasma levels of complement factor D, C5a and C3d.PloS one · 2013Trial
- Investigation of pan-immune inflammatory value in patients with age-related macular degeneration.BMC ophthalmology · 2026Article
- Role of complement factor D in cardiovascular and metabolic diseases.Frontiers in immunology · 2024Review
- The Role of the Complement Pathway in Clinical Progression of Geographic Atrophy: Analysis of the Phase III Chroma and Spectri Trials.Ophthalmology science · 2023Article
- Geographic Atrophy Management Consensus (GA-MAC): a Delphi panel study on identification, diagnosis and treatment.BMJ open ophthalmology · 2023Article
- Alternative Complement Pathway Inhibition by Lampalizumab: Analysis of Data From Chroma and Spectri Phase III Clinical Trials.Ophthalmology science · 2023Article
- Review
- Endothelial-derived complement factor D contributes to endothelial dysfunction in malignant nephrosclerosis via local complement activation.Hypertension research : official journal of the Japanese Society of Hypertension · 2023Article
- Genetic Aspects of Age-Related Macular Degeneration and Their Therapeutic Potential.International journal of molecular sciences · 2022Review
- Targeting the Complement Cascade for Treatment of Dry Age-Related Macular Degeneration.Biomedicines · 2022Review
- Review
- Age-Related Maculopathy Susceptibility 2 and Complement Factor H Polymorphism and Intraocular Complement Activation in Neovascular Age-Related Macular Degeneration.Ophthalmology science · 2022Article
- Retinal Drusen Are More Common and Larger in Systemic Lupus Erythematosus With Renal Impairment.Kidney international reports · 2022Article
- Complement Inhibition for Geographic Atrophy: A Tempting Target with Mixed Results.Journal of clinical medicine · 2021Article
- Complement Factor D (adipsin) Levels Are Elevated in Acquired Partial Lipodystrophy (Barraquer-Simons syndrome).International journal of molecular sciences · 2021Article
- High Myopia and the Complement System: Factor H in Myopic Maculopathy.Journal of clinical medicine · 2021Article
- A Review of Completed and Ongoing Complement Inhibitor Trials for Geographic Atrophy Secondary to Age-Related Macular Degeneration.Journal of clinical medicine · 2021Review
- Differential and Altered Spatial Distribution of Complement Expression in Age-Related Macular Degeneration.Investigative ophthalmology & visual science · 2021Article
- Complement Inhibitors in Age-Related Macular Degeneration: A Potential Therapeutic Option.Journal of immunology research · 2021Review
- Complement Factor D as a Strategic Target for Regulating the Alternative Complement Pathway.Frontiers in immunology · 2021Review
Corrections and comments
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Authors and funding
20 authors at 12 institutions in 5 countries.
Funding
Abstract
purposeTo examine the role of complement factor D (CFD) in age-related macular degeneration (AMD) by analysis of genetic association, copy number variation, and plasma CFD concentrations.
methodsSingle nucleotide polymorphisms (SNPs) in the CFD gene were genotyped and the results analyzed by binary logistic regression. CFD gene copy number was analyzed by gene copy number assay. Plasma CFD was measured by an enzyme-linked immunosorbent assay.
resultsGenetic association was found between CFD gene SNP rs3826945 and AMD (odds ratio 1.44; P = 0.028) in a small discovery case-control series (462 cases and 325 controls) and replicated in a combined cohorts meta-analysis of 4765 cases and 2693 controls, with an odds ratio of 1.11 (P = 0.032), with the association almost confined to females. Copy number variation in the CFD gene was identified in 13 out of 640 samples examined but there was no difference in frequency between AMD cases (1.3%) and controls (2.7%). Plasma CFD concentration was measured in 751 AMD cases and 474 controls and found to be elevated in AMD cases (P = 0.00025). The odds ratio for those in the highest versus lowest quartile for plasma CFD was 1.81. The difference in plasma CFD was again almost confined to females.
conclusionsCFD regulates activation of the alternative complement pathway, which is implicated in AMD pathogenesis. The authors found evidence for genetic association between a CFD gene SNP and AMD and a significant increase in plasma CFD concentration in AMD cases compared with controls, consistent with a role for CFD in AMD pathogenesis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.