Trial reportAmerican journal of physiology. Heart and circulatory physiology2012
Altered coronary vascular control during cold stress in healthy older adults.
Trial report in American journal of physiology. Heart and circulatory physiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 45 citations in OpenAlex.
- Intravenous phentolamine abolishes coronary vasoconstriction in response to mild central hypovolemia.Journal of applied physiology (Bethesda, Md. : 1985) · 2014Trial
- Effect of whole-body mild-cold exposure on arterial stiffness and central haemodynamics: a randomised, cross-over trial in healthy men and women.European journal of applied physiology · 2013Trial
- Impact of apparent temperature on specific cardiovascular disease admissions: a time-series study and association modification in Xiangyang, China.BMC public health · 2025Article
- Effects of acute hyperoxia on autonomic function and coronary tone in patients with peripheral artery disease.American journal of physiology. Heart and circulatory physiology · 2024Article
- Visualizing a Cold Stress-Specific Pulse Wave in Traditional Pulse Diagnosis ('Tight Pulse') Correlated with Vascular Changes in the Radial Artery Induced by a Cold Pressor Trial.Sensors (Basel, Switzerland) · 2024Article
- Effects of alpha-adrenergic receptor blockade on coronary circulation in postmenopausal women.European journal of applied physiology · 2023Article
- Seasonal dynamics of myocardial infarctions in regions with different types of a climate: a meta-analysis.The Egyptian heart journal : (EHJ) : official bulletin of the Egyptian Society of Cardiology · 2022Review
- Article
- Increased cold injuries and the effect of body mass index in patients with peripheral vascular disease.BMC public health · 2021Article
- Changes in electrocardiogram parameters during acute nonshivering cold exposure and associations with brown adipose tissue activity, plasma catecholamine levels, and brachial blood pressure in healthy adults.Physiological reports · 2021Article
- Investigation of the Reference Interval Values of Fasting Plasma Glucose, Blood Pressure, and Blood Lipids in the Longevity People Aged 90 Years Old and Above.Diabetes, metabolic syndrome and obesity : targets and therapy · 2021Article
- Similarity between carotid and coronary artery responses to sympathetic stimulation and the role of αJournal of applied physiology (Bethesda, Md. : 1985) · 2018Article
- Peripheral revascularization attenuates the exercise pressor reflex and increases coronary exercise hyperemia in peripheral arterial disease.Journal of applied physiology (Bethesda, Md. : 1985) · 2018Article
- Baseline aortic pulse wave velocity is associated with central and peripheral pressor responses during the cold pressor test in healthy subjects.Physiological reports · 2017Article
- Coronary Exercise Hyperemia Is Impaired in Patients with Peripheral Arterial Disease.Annals of vascular surgery · 2017Article
- β-Adrenergic receptor blockade impairs coronary exercise hyperemia in young men but not older men.American journal of physiology. Heart and circulatory physiology · 2014Article
- Coronary responses to cold air inhalation following afferent and efferent blockade.American journal of physiology. Heart and circulatory physiology · 2014Article
- β-Adrenergic blockade enhances coronary vasoconstrictor response to forehead cooling.American journal of physiology. Heart and circulatory physiology · 2014Article
- Effects of different cold-air exposure intensities on the risk of cardiovascular disease in healthy and hypertensive rats.International journal of biometeorology · 2014Article
- Coronary artery disease and age: beyond atherosclerosis.The Journal of physiology · 2013Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Cardiovascular-related mortality increases in the cold winter months, particularly in older adults. Previously, we reported that determinants of myocardial O(2) demand, such as the rate-pressure product, increase more in older adults compared with young adults during cold stress. The aim of the present study was to determine if aging influences the coronary hemodynamic response to cold stress in humans. Transthoracic Doppler echocardiography was used to noninvasively measure peak coronary blood velocity in the left anterior descending artery before and during acute (20 min) whole body cold stress in 10 young adults (25 ± 1 yr) and 11 older healthy adults (65 ± 2 yr). Coronary vascular resistance (diastolic blood pressure/peak coronary blood velocity), coronary perfusion time fraction (coronary perfusion time/R-R interval), and left ventricular wall stress were calculated. We found that cooling (via a water-perfused suit) increased left ventricular wall stress, a primary determinant of myocardial O(2) consumption, in both young and older adults, although the magnitude of this increase was nearly twofold greater in older adults (change of 9.1 ± 3.5% vs. 17.6 ± 3.2%, P < 0.05, change from baseline in young and older adults and young vs. older adults). Despite the increased myocardial O(2) demand during cooling, coronary vasodilation (decreased coronary vascular resistance) occurred only in young adults (3.22 ± 0.23 to 2.85 ± 0.18 mmHg·cm(-1)·s(-1), P < 0.05) and not older adults (3.97 ± 0.24 to 3.79 ± 0.27 mmHg·cm(-1)·s(-1), P > 0.05). Consistent with a blunted coronary vascular response, absolute coronary perfusion time tended to decrease (P = 0.13) and coronary perfusion time fraction decreased (P < 0.05) during cooling in older adults but not young adults. Collectively, these data suggest that older adults demonstrate an altered coronary hemodynamic response to acute cold stress.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.