Evidence map›Paper›PMID 22003003›Full record

ReviewVascular medicine (London, England)2011

Personalized vascular medicine: individualizing drug therapy.

Emil M Degoma, Giovanni Rivera, Scott M Lilly, M Haris U Usman, Emile R Mohler

Open access · greenAbstract readReview
In one paragraph

Review in Vascular medicine (London, England), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.8field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 26 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Personalized medicine in cardiovascular diseases.Korean circulation journal · 2012
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Emil M DegomaDivision of Cardiovascular Medicine, University of Pennsylvania, Philadelphia, USA. Emil.deGoma@uphs.upenn.edu
Giovanni Rivera
Scott M Lilly
M Haris U Usman
Emile R Mohler
University of Pennsylvania · US

Funding

Research career training in vascular medicineK12HL083772 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI MOHLER, EMILE R. · 2007 to 2012
$3.1M
NHLBI NIH HHS K12 HL083772NHLBI NIH HHS K12 HL083772-01
6 · The paper itself

Abstract

Personalized medicine refers to the application of an individual's biological fingerprint - the comprehensive dataset of unique biological information - to optimize medical care. While the principle itself is straightforward, its implementation remains challenging. Advances in pharmacogenomics as well as functional assays of vascular biology now permit improved characterization of an individual's response to medical therapy for vascular disease. This review describes novel strategies designed to permit tailoring of four major pharmacotherapeutic drug classes within vascular medicine: antiplatelet therapy, antihypertensive therapy, lipid-lowering therapy, and antithrombotic therapy. Translation to routine clinical practice awaits the results of ongoing randomized clinical trials comparing personalized approaches with standard of care management.

Indexed as

Antihypertensive AgentsCardiovascular DiseasesFibrinolytic AgentsGenotyping TechniquesHumansHypolipidemic AgentsPlatelet Aggregation InhibitorsPrecision MedicineAntihypertensive AgentsFibrinolytic AgentsHypolipidemic AgentsPlatelet Aggregation Inhibitors

Identifiers

PMID22003003
PMCPMC3761360
OpenAlexW2169759047

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.