Evidence map›Paper›PMID 22002930›Full record

ReviewCytoskeleton (Hoboken, N.J.)2011

Cease-fire at the leading edge: new perspectives on actin filament branching, debranching, and cross-linking.

Casey A Ydenberg, Benjamin A Smith, Dennis Breitsprecher, Jeff Gelles, Bruce L Goode

Abstract readReview
In one paragraph

Review in Cytoskeleton (Hoboken, N.J.), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed.

  1. Article
  2. Mechanisms of actin disassembly and turnover.The Journal of cell biology · 2023
    Review
  3. Getting cells into shape by calcium-dependent actin cross-linking proteins.Frontiers in cell and developmental biology · 2023
    Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. GMF as an Actin Network Remodeling Factor.Trends in cell biology · 2018
    Review
  10. Review
  11. Article
  12. Review
  13. Review
  14. Actin-interacting protein 1 controls assembly and permeability of intestinal epithelial apical junctions.American journal of physiology. Gastrointestinal and liver physiology · 2015
    Article
  15. Article
  16. Review
  17. Review
  18. Visualization of uncorrelated, tandem symmetry mismatches in the internal genome packaging apparatus of bacteriophage T7.Proceedings of the National Academy of Sciences of the United States of America · 2013
    Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Casey A YdenbergDepartment of Biology and Rosenstiel Basic Medical Sciences Research Center, Brandeis University, Waltham, Massachusetts 02454, USA.
Benjamin A Smith
Dennis Breitsprecher
Jeff Gelles
Bruce L Goode

Funding

MECHNISMS REGULATING ACTIN ASSEMBLYR01GM063691 · NIGMS · BRANDEIS UNIVERSITY · PI GOODE, BRUCE L · 2002 to 2019
$7.5M
Functional Mechanisms of Processive Motor ATPasesR37GM043369 · NIGMS · BRANDEIS UNIVERSITY · PI GELLES, JEFF · 2002 to 2011
$5.0M
Molecular Mechanisms coordinating the actin and microtubule cytoskeletonsR01GM098143 · NIGMS · BRANDEIS UNIVERSITY · PI GELLES, JEFF, GOODE, BRUCE L · 2012 to 2019
$2.6M
BIOPHYSICS AND ENZYMOLOGY OF KINESIN MOVEMENTR01GM043369 · NIGMS · BRANDEIS UNIVERSITY · PI GELLES, JEFF · 1991 to 2001
$587k
NIGMS NIH HHS GM063691NIGMS NIH HHS GM43369NIGMS NIH HHS R01 GM043369NIGMS NIH HHS R01 GM063691NIGMS NIH HHS R01 GM098143NIGMS NIH HHS R37 GM043369
6 · The paper itself

Abstract

Membrane protrusion at the leading edge of migrating cells is driven by the polymerization of actin. Recent studies using advanced imaging techniques raised a lively controversy about the morphology of these filaments; however, common ground between the two sides now appears to have been found. Here we discuss how the controversy has led to a deeper consideration of the architecture of actin networks underlying cell migration, and has helped define new challenges that lie ahead.

Indexed as

Actin CytoskeletonCell MovementCytoskeletonHumansMicrofilament ProteinsMicrofilament Proteins

Identifiers

PMID22002930
PMCPMC3218376

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.