ArticleInfection2012
Adherence to guidelines for antibiotic prophylaxis in surgery patients in German hospitals: a multicentre evaluation involving pharmacy interns.
Article in Infection, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 3 of them syntheses that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
36 citing papers in PubMed, 3 syntheses or guidelines pooled it, 96 citations in OpenAlex.
- Development of a generalised tool for evaluating success of clinical practice guidelines implementation (A-GIST).BMJ evidence-based medicine · 2025Pooled it
- Pooled it
- Adherence to guidelines for surgical antibiotic prophylaxis: a review.The Brazilian journal of infectious diseases : an official publication of the Brazilian Society of Infectious DiseasesPooled it
- Do we need postoperative antibiotics in supratentorial clean neurosurgery? A prospective, randomized, single-blind, and placebo-controlled study.Turkish journal of medical sciences · 2022Trial
- Impact of pharmacist interventions on drug-related problems in general surgery patients: a randomised controlled trial.European journal of hospital pharmacy : science and practice · 2021Trial
- Patterns of Surgical Prophylaxis Prescribing for Dentoalveolar Procedures in Australian Hospitals: 2016-2022.Australian dental journal · 2026Article
- Effects of implementing a clinical pathway on antibiotic prophylaxis for patients who underwent an elective surgery.Scientific reports · 2022Article
- Polish Medical Doctors' Opinions on Available Resources and Information Campaigns concerning Antibiotics and Antibiotic Resistance, a Cross-Sectional Study.Antibiotics (Basel, Switzerland) · 2022Article
- Antimicrobial prophylaxis uses and incidence of surgical site infection in Jayanagar General Hospital, Bangalore, India.Journal of family medicine and primary care · 2022Article
- Compliance with Antibiotics Prophylaxis Guideline in Surgical Patients in ICUs of a Teaching Referral Hospital.Health services insights · 2022Article
- Clinical and bacteriological profile of abdominal surgical site infections in an Indian Hospital.Bioinformation · 2022Article
- Barriers and Facilitators in Perioperative Antibiotic Prophylaxis: A Mixed-Methods Study in a Small Island Setting.Antibiotics (Basel, Switzerland) · 2021Article
- Impact of bodyweight-adjusted antimicrobial prophylaxis on surgical-site infection rates.BJS open · 2021Observational
- Perioperative Antibiotic Prophylaxis: An Educative Intervention Significantly Increases Compliance.Journal of clinical medicine research · 2021Article
- Understanding surgical antimicrobial prescribing behaviour in the hospital setting: a systematic review and meta-ethnography protocol.Systematic reviews · 2020Article
- Factors associated with antimicrobial choice for surgical prophylaxis in Australia.JAC-antimicrobial resistance · 2020Article
- [Multicenter study of adherence to guidelines on surgical prophylaxis and the determinants of non-adherence in ArgentinaEstudo multicêntrico sobre a adesão a diretrizes de profilaxia cirúrgica e seus determinantes na Argentina].Revista panamericana de salud publica = Pan American journal of public health · 2020Article
- Evaluation of Surgical Antimicrobial Prophylaxis and Incidence of Surgical Site Infection at Borumeda Hospital, Northeast Ethiopia: Retrospective Cross-Sectional Study.Drug, healthcare and patient safety · 2020Article
- Appropriateness of Surgical Antimicrobial Prophylaxis Practices in Australia.JAMA network open · 2019Article
- Antimicrobial Prophylaxis Redosing Reduces Surgical Site Infection Risk in Prolonged Duration Surgery Irrespective of Its Timing.World journal of surgery · 2019Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND AND
aimSurgical site infections (SSIs) are associated with a high morbidity, mortality and healthcare costs. The prevention of SSIs is based on a combination of preoperative preparation, surgical techniques, perioperative antibiotic prophylaxis (PAP) and postoperative wound care. Despite an abundance of evidence demonstrating the effectiveness of antimicrobials to prevent SSIs, the use of antimicrobial prophylaxis in this clinical setting is associated with inappropriate timing and selection and excessive duration of administration. To date, pharmacy interns (PIs) have not been involved in this process. The aim of this study was to evaluate feasibility of involving PIs in monitoring adherence to the guidelines for antibiotic prophylaxis in surgery patients.
methodsThe study was conducted in seven hospitals in Germany within the framework of the project "Pharmacy interns on the ward" (P-STAT2). Twenty-seven PIs participated, either from either May to October 2008 or from November 2008 to April 2009. Each patient admitted to the participating wards was consecutively monitored. PIs documented the antibiotic prophylaxis and checked the adherence with the hospital ward's PAP guidelines taking both the choice of antibiotic drug and the duration of PAP into account. The costs of antibiotics, personnel and material were calculated in cases of non-adherence with guidelines.
resultsThis is the first time that PIs were involved in monitoring antibiotic prophylaxis guidelines. A total of 6,167 patients were enrolled (mean age 58.3 ± 19.6 years; 47.1% male); of these, 5,064 patients underwent surgery and were ultimately available for evaluation. Guidelines for antibiotic prophylaxis were followed in 70.7% of the cases.
conclusionsThe study revealed that many patients do not receive the appropriate antibiotic prophylaxis despite the fact that guidelines are in place. Based on these results, we conclude that PIs may play an important role in antibiotic prophylaxis management.
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