Evidence map›Paper›PMID 22002702›Full record

ReviewDer Chirurg; Zeitschrift fur alle Gebiete der operativen Medizen2011

[Gastric cancer and adenocarcinoma of the esophagogastric junction: principles of neoadjuvant therapy].

F Lordick, K Ott, A Sendler

Abstract readEnglish AbstractReview
PubMed Publisher
In one paragraph

Review in Der Chirurg; Zeitschrift fur alle Gebiete der operativen Medizen, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.2field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. [Palliative surgery in visceral medicine. Exemplified by colorectal and gastric cancer].Der Chirurg; Zeitschrift fur alle Gebiete der operativen Medizen · 2016
    Observational
  3. [Palliative treatment of advanced gastric cancer from surgical point of view].Der Chirurg; Zeitschrift fur alle Gebiete der operativen Medizen · 2015
    Observational
  4. Review
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 3 institutions in 1 country.

F LordickMedizinische Klinik III, Innere Medizin, Hämatologie und Onkologie, Klinikum Braunschweig, Celler Str. 38, 38114, Braunschweig, Deutschland. medklinik3@klinikum-braunschweig.de
K Ott
A Sendler
Chirurgische Universitätsklinik Heidelberg · DEKlinikum Braunschweig · DEMünchen Klinik · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

According to the current European and German S3 guidelines, neoadjuvant chemotherapy is now an integral part of the treatment of locally advanced gastric cancer and adenocarcinoma of the esophagogastric junction. Neoadjuvant therapy seeks to achieve downsizing of the primary tumor, lowering of the T and N categories and eradication of micrometastases. As the indications for neoadjuvant treatment are based on pretherapeutic information alone, a sophisticated clinical staging plays a central role. Despite all progress made in the field of diagnostic work-up, clinical staging often fails. Despite this fact, controlled randomized trials showed that neoadjuvant chemotherapy enhances the rate of curative (R0) resections and reduces the likelihood of systemic relapse. Overall, survival can be improved by neoadjuvant chemotherapy. The current research is focused on the molecular prediction of response and early response monitoring with functional imaging. New targeted drugs are being integrated into the peri-operative treatment.

Indexed as

Esophagogastric JunctionNeoadjuvant TherapyAdenocarcinomaCombined Modality TherapyEsophageal NeoplasmsGuideline AdherenceHumansNeoplasm Recurrence, LocalNeoplasm StagingPrognosisStomach NeoplasmsSurvival Rate

Identifiers

PMID22002702
OpenAlexW10605841

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.