ArticleJournal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology2011
High-resolution imaging of human atherosclerotic carotid plaques with micro 18F-FDG PET scanning exploring plaque vulnerability.
Article in Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.
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Who cites it
27 citing papers in PubMed, 1 synthesis or guideline pooled it, 67 citations in OpenAlex.
- Molecular imaging of carotid artery atherosclerosis with PET: a systematic review.European journal of nuclear medicine and molecular imaging · 2020Pooled it
- [Molecular imaging and biology · 2021Trial
- Molecular imaging of atherosclerotic plaque vulnerability: a narrative review.The international journal of cardiovascular imaging · 2026Review
- Heterogeneity of vascular inflammation in obstructive sleep apnea: effects of continuous positive airway pressure therapy.Annals of the American Thoracic Society · 2026Article
- MRI ensemble model of plaque and perivascular adipose tissue as PET-equivalent for identifying carotid atherosclerotic inflammation.EJNMMI research · 2025Article
- Characterization of a novel model for atherosclerosis imaging: the apolipoprotein E-deficient rat.EJNMMI research · 2023Article
- Novel Imaging-Based Biomarkers for Identifying Carotid Plaque Vulnerability.Biomolecules · 2023Review
- SPECT/CT imaging of inflammation and calcification in human carotid atherosclerosis to identify the plaque at risk of rupture.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2022Article
- [Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2022Article
- Carotid plaque stenosis, metabolism and flow dynamics: Important determinants of atherosclerotic risk?Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2022Article
- Carotid Plaque Composition and the Importance of Non-Invasive in Imaging Stroke Prevention.Frontiers in cardiovascular medicine · 2022Review
- Metabolic regulation of macrophage proliferation and function in atherosclerosis.Current opinion in lipidology · 2021Review
- Feasibility of ex vivo fluorescence imaging of angiogenesis in (non-) culprit human carotid atherosclerotic plaques using bevacizumab-800CW.Scientific reports · 2021Observational
- Imaging of inflammatory cellular protagonists in human atherosclerosis: a dual-isotope SPECT approach.European journal of nuclear medicine and molecular imaging · 2020Article
- Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2019Article
- Imaging the event-prone coronary artery plaque.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2019Review
- Monocyte and haematopoietic progenitor reprogramming as common mechanism underlying chronic inflammatory and cardiovascular diseases.European heart journal · 2018Review
- Thresholds for Arterial Wall Inflammation Quantified byJACC. Cardiovascular imaging · 2016Observational
- Future imaging of atherosclerosis: molecular imaging of coronary atherosclerosis with (18)F positron emission tomography.Cardiovascular diagnosis and therapy · 2016Review
- Incremental value of PET and MRI in the evaluation of cardiovascular abnormalities.Insights into imaging · 2016Review
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimsFDG-PET can be used to identify vulnerable plaques in atherosclerotic disease. Clinical FDG-PET camera systems are restricted in terms of resolution for the visualization of detailed inflammation patterns in smaller vascular structures. The aim of the study is to evaluate the possible added value of a high-resolution microPET system in excised carotid plaques using FDG. METHODS AND
resultsIn this study, 17 patients with planned carotid endarterectomy were included. Excised plaques were incubated in FDG and subsequently imaged with microPET. Macrophage presence in plaques was evaluated semi-quantitatively by immunohistochemistry. Plaque calcification was assessed additionally with CT and correlated to FDG uptake. Finally, FDG uptake and macrophage infiltration were compared with patient symptomatology. Heterogeneous distributions and variable intensities of FDG uptake were found within the plaques. A positive correlation between the distribution of macrophages and the FDG uptake (r = 0.68, P < .01) was found. A negative correlation was found between areas of calcifications and FDG uptake (r = -0.84, P < .001). Ratio FDG(max) values as well as degree of CD68 accumulation were significantly higher in CVA patients compared with TIA or amaurosis fugax patients (P < .05) and CVA patients compared with asymptomatic patients (P < .05).
conclusionThis ex vivo study demonstrates that excised carotid plaques can be visualized in detail using FDG microPET. Enhancement of clinical PET/CT resolution for similar imaging results in patients is needed.
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