ReviewJournal of neuro-oncology2012
Genomic profiling of glioblastoma: convergence of fundamental biologic tenets and novel insights.
Review in Journal of neuro-oncology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed.
- Development of a Prodrug of Camptothecin for Enhanced Treatment of Glioblastoma Multiforme.Molecular pharmaceutics · 2021Article
- Article
- A Glioblastoma Genomics Primer for Clinicians.Medical research archives · 2020Article
- Increased LGALS3 expression independently predicts shorter overall survival in patients with the proneural subtype of glioblastoma.Cancer medicine · 2019Article
- 20(S)-ginsenoside-Rg3 reverses temozolomide resistance and restrains epithelial-mesenchymal transition progression in glioblastoma.Cancer science · 2019Article
- Angiogenin Upregulation Independently Predicts Unfavorable Overall Survival in Proneural Subtype of Glioblastoma.Technology in cancer research & treatment · 2019Article
- Article
- Survival trends of oligodendroglial tumor patients and associated clinical practice patterns: a SEER-based analysis.Journal of neuro-oncology · 2017Review
- Advances in epigenetic glioblastoma therapy.Oncotarget · 2017Review
- MicroRNA-96 Regulates Apoptosis by Targeting PDCD4 in Human Glioma Cells.Technology in cancer research & treatment · 2017Article
- Differential localization of glioblastoma subtype: implications on glioblastoma pathogenesis.Oncotarget · 2016Article
- MiR-519a functions as a tumor suppressor in glioma by targeting the oncogenic STAT3 pathway.Journal of neuro-oncology · 2016Article
- Optimizing preservation of extracellular vesicular miRNAs derived from clinical cerebrospinal fluid.Cancer biomarkers : section A of Disease markers · 2016Article
- Survival trends of grade I, II, and III astrocytoma patients and associated clinical practice patterns between 1999 and 2010: A SEER-based analysis.Neuro-oncology practice · 2016Article
- IDH mutation and MGMT promoter methylation in glioblastoma: results of a prospective registry.Oncotarget · 2015Article
- Targeting the cancer cell state.Cell cycle (Georgetown, Tex.) · 2015Article
- Dynamic epigenetic regulation of glioblastoma tumorigenicity through LSD1 modulation of MYC expression.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Orthogonal targeting of EGFRvIII expressing glioblastomas through simultaneous EGFR and PLK1 inhibition.Oncotarget · 2015Article
- HDAC4, a prognostic and chromosomal instability marker, refines the predictive value of MGMT promoter methylation.Journal of neuro-oncology · 2015Article
- Differential Effects of Cold Atmospheric Plasma in the Treatment of Malignant Glioma.PloS one · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
With advances in genomic profiling and sequencing technology, we are beginning to understand the landscape of the genetic events that accumulated during the neoplastic process. The insights gleamed from these genomic profiling studies with regards to glioblastoma etiology has been particularly satisfying because it cemented the clinical pertinence of major concepts in cancer biology-concepts developed over the past three decades. This article will review how the glioblastoma genomic data set serves as an illustrative platform for the concepts put forward by Hanahan and Weinberg on the cancer phenotype. The picture emerging suggests that most glioblastomas evolve along a multitude of pathways rather than a single defined pathway. In this context, the article will further provide a discussion of the subtypes of glioblastoma as they relate to key principles of developmental neurobiology.
Indexed as
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.