ArticleEndocrine-related cancer2011
Total oxidant/antioxidant status in sera of patients with thyroid cancers.
Article in Endocrine-related cancer, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 64 papers.
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Who cites it
64 citing papers in PubMed, 131 citations in OpenAlex.
- Type 2 Diabetes Mellitus in Patients with Different Types of Thyroid Nodular Lesions Among Western Romanian Patients: A Comprehensive Clinical, Biochemical, and Hormonal Analysis.Medicina (Kaunas, Lithuania) · 2025Article
- Comparative effects of dexpanthenol and thymoquinone on colistin-induced neurotoxicity in rats.Naunyn-Schmiedeberg's archives of pharmacology · 2025Article
- Mechanistic Aspects of Inflammation and Oxidative Stress and Their Association With Thyroid Cancer Risk.Cancer medicine · 2025Review
- Modulation of Intestinal Flora: a Novel Immunotherapeutic Approach for Enhancing Thyroid Cancer Treatment.Probiotics and antimicrobial proteins · 2025Review
- Single-cell and machine learning integration reveals OS-driven CCND1 promotes an aggressive phenotype in papillary thyroid carcinoma.Frontiers in immunology · 2025Article
- Associations Among Obstructive Sleep Apnea, Thyroid Function and Morphology Changes.Nature and science of sleep · 2025Article
- Preoperative oxidative stress as a biomarker of postoperative complications in colorectal cancer patients.Przeglad gastroenterologiczny · 2025Article
- TheFrontiers in nutrition · 2025Article
- Vitamin C in the Management of Thyroid Cancer: A Highway to New Treatment?Antioxidants (Basel, Switzerland) · 2024Review
- From balance to imbalance: disruption of plasma glutathione concentration in micropapillary thyroid carcinoma.Thyroid research · 2024Article
- Associations of oxidative stress, metabolic disorders in colorectal cancer patients.Przeglad gastroenterologiczny · 2024Article
- Monitoring Metastatic Colorectal Cancer Progression According to Reactive Oxygen Metabolite Derivative Levels.Cancers · 2023Article
- Influence of the circadian cycle, sex and production stage on the reference values of parameters related to stress and pathology in porcine saliva.Porcine health management · 2023Article
- MiR-146b-5p regulates the scavenging effect of GPx-3 on peroxide in papillary thyroid cancer cells.Heliyon · 2023Article
- The Inverse Association of Serum Magnesium with Papillary Thyroid Cancer in Thyroid Nodules: a Cross-Sectional Survey Based on Thyroidectomy Population.Biological trace element research · 2023Article
- Could Oxidative Stress Play a Role in the Development and Clinical Management of Differentiated Thyroid Cancer?Cancers · 2023Review
- Is Glucose-6-Phosphate Dehydrogenase Deficiency a Risk Factor for Autoimmune Thyroid Disease? A Retrospective Case-Control Study.International journal of environmental research and public health · 2023Article
- Analysis of redox status and HDL subclasses in patients with lymphoma and the associations with FDG-PET/CT findings.Frontiers in oncology · 2023Article
- The Relationship between Circulating Irisin and Oxidative Stress in Gastric and Colorectal Cancer Patients.Asian Pacific journal of cancer prevention : APJCP · 2022Article
- Association of thiol/disulphide homeostasis with Bethesda classification of thyroid nodules and thyroid cancer.Turkish journal of medical sciences · 2022Article
4 more citing papers are in PubMed but not listed here.
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6 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
Oxidative stress is considered to be involved in the pathophysiology of all cancers. In order to evaluate the total oxidant/antioxidant status in patients with thyroid cancer and to investigate the relationship between oxidative stress parameters and serum thyroid profiles among thyroid cancer patients and various controls, we determined oxidative status including total antioxidant status (TAS) and total oxidant status (TOS) and calculation of oxidative stress index (OSI) in sera in 82 thyroid cancer patients, 56 benign thyroid disease patients, and 50 healthy controls. It was found that serum TAS levels were significantly lower in patients with thyroid cancer than in controls (P<0.001), while serum TOS levels and OSI values were significantly higher (both P<0.001) in the cancer patients. No significant correlations were observed between various oxidative stress markers and thyroid profiles in either the thyroid cancer patients or the controls. Receiver operating characteristic curve analysis demonstrated that OSI was the best indicator for distinguishing cancer patients from benign thyroid diseased or healthy controls, followed by TOS and TAS. Risk estimate statistics also indicated that TOS and/or OSI were good risk factors to discriminate patients with thyroid cancer from two controls. These findings suggested that oxidants are increased and antioxidants are decreased in patients with thyroid cancer. OSI may be a more useful oxidative stress biomarker than TAS and TOS for monitoring the clinical status of thyroid cancer patients.
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