ArticleGenomics2011
Transcriptional regulation of co-expressed microRNA target genes.
Article in Genomics, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Analyzing the Role of MicroRNAs in Schizophrenia in the Context of Common Genetic Risk Variants.JAMA psychiatry · 2016Pooled it
- A computational modeling of pri-miRNA expression.PloS one · 2024Article
- miRNA-199a-5p/SLC2A1 axis regulates glucose metabolism in non-small cell lung cancer.Journal of Cancer · 2022Article
- miR-373-3p Regulates Invasion and Migration Abilities of Trophoblast Cells via Targeted CD44 and Radixin.International journal of molecular sciences · 2021Article
- Position-wise binding preference is important for miRNA target site prediction.Bioinformatics (Oxford, England) · 2020Article
- Unravelling miRNA regulation in yield of rice (Oryza sativa) based on differential network model.Scientific reports · 2018Article
- CCmiR: a computational approach for competitive and cooperative microRNA binding prediction.Bioinformatics (Oxford, England) · 2018Article
- MicroRNAs contribute to postnatal development of laminar differences and neuronal subtypes in the rat medial entorhinal cortex.Brain structure & function · 2017Article
- RNA-Seq reveals MicroRNA expression signature and genetic polymorphism associated with growth and muscle quality traits in rainbow trout.Scientific reports · 2017Article
- Prognostic cancer gene signatures share common regulatory motifs.Scientific reports · 2017Article
- Stroke and Circulating Extracellular RNAs.Stroke · 2017Observational
- Unveiling of miRNA Expression Patterns in Purkinje Cells During Development.Cerebellum (London, England) · 2017Article
- Targeting microRNAs: a new action mechanism of natural compounds.Oncotarget · 2017Review
- Analysis of Co-Associated Transcription Factors via Ordered Adjacency Differences on Motif Distribution.Scientific reports · 2017Article
- Effect of TGF-β/smad signaling pathway blocking on expression profiles of miR-335, miR-150, miR-194, miR-27a, and miR-199a of hepatic stellate cells (HSCs).Gastroenterology and hepatology from bed to bench · 2017Article
- TarPmiR: a new approach for microRNA target site prediction.Bioinformatics (Oxford, England) · 2016Article
- Review
- MicroRNA modules prefer to bind weak and unconventional target sites.Bioinformatics (Oxford, England) · 2015Article
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Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
MicroRNAs play pivotal roles in gene regulation. Despite various research efforts on microRNAs, how microRNA target genes are transcriptionally regulated and how the transcriptional regulation of microRNA target genes relates to that of the microRNA genes are not well studied. By investigating the transcriptional regulation of microRNA target genes, we found that different groups of target genes of the same microRNA are co-expressed under different conditions, and these groups rarely overlap with each other for the majority of microRNAs. We also discovered that co-expressed microRNA target genes are often co-regulated, and different groups of target genes of the same microRNA are often regulated differently. In addition, we observed that transcription factors regulating a microRNA gene often regulate its target genes. Our study sheds light on the regulation of microRNA target genes, which will facilitate the prediction of microRNA target genes and the understanding of the transcriptional regulation of microRNA genes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.