Trial reportJournal of clinical anesthesia2012
The effect of low versus high tidal volume ventilation on inflammatory markers in healthy individuals undergoing posterior spine fusion in the prone position: a randomized controlled trial.
Trial report in Journal of clinical anesthesia, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 3 syntheses or guidelines pooled it, 42 citations in OpenAlex.
- Intraoperative use of low volume ventilation to decrease postoperative mortality, mechanical ventilation, lengths of stay and lung injury in adults without acute lung injury.The Cochrane database of systematic reviews · 2018Pooled it
- Lung protective ventilation in patients undergoing major surgery: a systematic review incorporating a Bayesian approach.BMJ open · 2015Pooled it
- Effect of lung-protective ventilation with lower tidal volumes on clinical outcomes among patients undergoing surgery: a meta-analysis of randomized controlled trials.CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne · 2015Pooled it
- Intraoperative protective ventilation in patients undergoing major neurosurgical interventions: a randomized clinical trial.BMC anesthesiology · 2021Trial
- The Effect of Pressure-Controlled Ventilation and Volume-Controlled Ventilation in Prone Position on Pulmonary Mechanics and Inflammatory Markers.Inflammation · 2016Trial
- Interleukin-10 and Zonulin Are Associated With Postoperative Delayed Gastric Emptying in Critically Ill Surgical Pediatric Patients: A Prospective Pilot Study.JPEN. Journal of parenteral and enteral nutrition · 2020Article
- Individualized lung protective ventilation vs. conventional ventilation during general anesthesia in laparoscopic total hysterectomy.Experimental and therapeutic medicine · 2020Article
- Article
- Application of intraoperative lung-protective ventilation varies in accordance with the knowledge of anaesthesiologists: a single-Centre questionnaire study and a retrospective observational study.BMC anesthesiology · 2018Observational
- Perioperative Retinal Artery Occlusion: Incidence and Risk Factors in Spinal Fusion Surgery From the US National Inpatient Sample 1998-2013.Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society · 2018Article
- Interaction between peri-operative blood transfusion, tidal volume, airway pressure and postoperative ARDS: an individual patient data meta-analysis.Annals of translational medicine · 2018Article
- Preventing Ventilator-Associated Lung Injury: A Perioperative Perspective.Frontiers in medicine · 2016Article
- Impact of a lung-protective ventilatory strategy on systemic and pulmonary inflammatory responses during laparoscopic surgery: is it really helpful?Inflammation · 2015Article
- Pulmonary complications after spine surgery.World journal of orthopedics · 2012Article
- Low tidal volume ventilation strategy and organ functions in patients with pre-existing systemic inflammatory response.Journal of anaesthesiology, clinical pharmacologyArticle
- The effect of low versus high tidal volume ventilation on inflammatory markers in animal model undergoing lung ventilation: A prospective study.Saudi journal of anaesthesiaArticle
- Intraoperative low tidal volume ventilation strategy has no benefits during laparoscopic cholecystectomy.Journal of anaesthesiology, clinical pharmacologyArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
Abstract
STUDY
objectiveTo evaluate the effect of ventilation strategy on markers of inflammation in patients undergoing spine surgery in the prone position.
designRandomized controlled trial.
settingUniversity-affiliated teaching hospital. PATIENTS: 26 ASA physical status 1 and 2 patients scheduled for elective primary lumbar decompression and fusion in the prone position.
interventionsPatients were randomized to receive mechanical ventilation with either a tidal volume (V(T)) of 12 mL/kg ideal body weight with zero positive end-expiratory pressure (PEEP) or V(T) of 6 mL/kg ideal body weight with PEEP of 8 cm H(2)O. MEASUREMENTS: Plasma levels of interleukin (IL)-6 and IL-8 were determined at the beginning of ventilation and at 6 and 12 hours later. Urinary levels of desmosine were determined at the beginning of ventilation and on postoperative days 1 and 3. MAIN
resultsA significant increase in IL-6, IL-8, and urine desmosine levels was noted over time compared with baseline (P < 0.01). However, no significant difference in the levels of markers was seen between the groups at any time point when controlling for demographics, ASA physical status, body mass index, duration of ventilation, or estimated blood loss.
conclusionsAlthough markers of inflammation are increased after posterior spine fusion surgery, ventilation strategy has minimal impact on markers of systemic inflammation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.