ArticleResuscitation2012
Coordination and management of multicenter clinical studies in trauma: Experience from the PRospective Observational Multicenter Major Trauma Transfusion (PROMMTT) Study.
Article in Resuscitation, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03144427 (The Acute Burn Resuscitation Multicenter Prospective Observational Trial), which is not on this map. Cited by 36 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Acute Burn Resuscitation Multicenter Prospective Observational Trial
Who cites it
36 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Buffered solutions versus 0.9% saline for resuscitation in critically ill adults and children.The Cochrane database of systematic reviews · 2019Pooled it
- Balanced Component and Whole-Blood Transfusion Practices in US Trauma Centers.JAMA network open · 2026Article
- Evolving roles of Data Coordinating Centers in multisite research: Challenges and adaptations from a rapid scoping review.Journal of clinical and translational science · 2026Review
- Adopting common data elements (CDEs) for the National Trauma Research Repository (NTRR): the results of an acute hospital Delphi survey.Trauma surgery & acute care open · 2026Article
- A Comprehensive Review of Fluid Resuscitation Strategies in Traumatic Brain Injury.Journal of clinical medicine · 2025Review
- Is there a need for fresh frozen plasma and platelet transfusion in trauma patients receiving submassive transfusion?Trauma surgery & acute care open · 2024Article
- The focused assessment with sonography in trauma (FAST) in hypotensive injured patients frequently fails to identify the need for laparotomy: a multi-institutional pragmatic study.Trauma surgery & acute care open · 2019Article
- Nonparametric estimation of median survival times with applications to multi-site or multi-center studies.PloS one · 2018Observational
- The current understanding of trauma-induced coagulopathy (TIC): a focused review on pathophysiology.Internal and emergency medicine · 2017Review
- Estimating the ratio of multivariate recurrent event rates with application to a blood transfusion study.Statistical methods in medical research · 2017Article
- The Impact of Pre-Hospital Administration of Lactated Ringer's Solution versus Normal Saline in Patients with Traumatic Brain Injury.Journal of neurotrauma · 2016Observational
- A joint latent class analysis for adjusting survival bias with application to a trauma transfusion study.Statistics in medicine · 2016Article
- Benefits of Initial Limited Crystalloid Resuscitation in Severely Injured Trauma Patients at Emergency Department.Journal of clinical medicine research · 2015Article
- A joint latent class model for classifying severely hemorrhaging trauma patients.BMC research notes · 2015Article
- An abdominal computed tomography may be safe in selected hypotensive trauma patients with positive Focused Assessment with Sonography in Trauma examination.American journal of surgery · 2015Observational
- Article
- Cellular microparticle and thrombogram phenotypes in the Prospective Observational Multicenter Major Trauma Transfusion (PROMMTT) study: correlation with coagulopathy.Thrombosis research · 2014Observational
- Trauma-Induced Coagulopathy.Current anesthesiology reports · 2014Article
- New evidence in trauma resuscitation - is 1:1:1 the answer?Perioperative medicine (London, England) · 2013Article
- Seven deadly sins in trauma outcomes research: an epidemiologic post mortem for major causes of bias.The journal of trauma and acute care surgery · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
15 authors.
Funding
Abstract
aimEarly death due to hemorrhage is a major consequence of traumatic injury. Transfusion practices differ among hospitals and it is unknown which transfusion practices improve survival. This report describes the experience of the PRospective Observational Multicenter Major Trauma Transfusion (PROMMTT) Study Data Coordination Center in designing and coordinating a study to examine transfusion practices at ten Level 1 trauma centers in the US.
methodsPROMMTT was a multisite prospective observational study of severely injured transfused trauma patients. The clinical sites collected real-time information on the timing and amounts of blood product infusions as well as colloids and crystalloids, vital signs, initial diagnostic and clinical laboratory tests, life saving interventions and other clinical care data.
resultsBetween July 2009 and October 2010, PROMMTT screened 12,561 trauma admissions and enrolled 1245 patients who received one or more blood transfusions within 6h of Emergency Department (ED) admission. A total of 297 massive transfusions were observed over the course of the study at a combined rate of 5.0 massive transfusion patients/week.
conclusionPROMMTT is the first multisite study to collect real-time prospective data on trauma patients requiring transfusion. Support from the Department of Defense and collaborative expertise from the ten participating centers helped to demonstrate the feasibility of prospective trauma transfusion studies. The observational data collected from this study will be an invaluable resource for research in trauma surgery and it will guide the design and conduct of future randomized trials.
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