ArticleInjury2012
An in vivo rodent model of contraction-induced injury in the quadriceps muscle.
Article in Injury, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 27 citations in OpenAlex.
- HIF prolyl hydroxylase inhibition protects skeletal muscle from eccentric contraction-induced injury.Skeletal muscle · 2018Trial
- A Novel Minimally Invasive Surgically Induced Skeletal Muscle Injury Model in Sheep.International journal of molecular sciences · 2024Article
- Pelvic floor injury during vaginal birth is life-altering and preventable: what can we do about it?American journal of obstetrics and gynecology · 2024Review
- Dosage-Adjusted Resistance Training in Mice with a Reduced Risk of Muscle Damage.Journal of visualized experiments : JoVE · 2022Article
- Article
- Duchenne muscular dystrophy hiPSC-derived myoblast drug screen identifies compounds that ameliorate disease in mdx mice.JCI insight · 2020Article
- Defects in sarcolemma repair and skeletal muscle function after injury in a mouse model of Niemann-Pick type A/B disease.Skeletal muscle · 2019Article
- Glycerol induces early fibrosis in regenerating rat skeletal muscle.The Journal of veterinary medical science · 2018Article
- Impaired contractile function of the supraspinatus in the acute period following a rotator cuff tear.BMC musculoskeletal disorders · 2017Article
- Cell death, clearance and immunity in the skeletal muscle.Cell death and differentiation · 2016Review
- A method to test contractility of the supraspinatus muscle in mouse, rat, and rabbit.Journal of applied physiology (Bethesda, Md. : 1985) · 2016Article
- In Vivo Assessment of Muscle Contractility in Animal Studies.Methods in molecular biology (Clifton, N.J.) · 2016Article
- SERCA1 overexpression minimizes skeletal muscle damage in dystrophic mouse models.American journal of physiology. Cell physiology · 2015Article
- Recovery of altered neuromuscular junction morphology and muscle function in mdx mice after injury.Cellular and molecular life sciences : CMLS · 2015Article
- A stepwise procedure to test contractility and susceptibility to injury for the rodent quadriceps muscle.Journal of biological methods · 2014Article
- Genetic silencing of Nrf2 enhances X-ROS in dysferlin-deficient muscle.Frontiers in physiology · 2014Article
- Effects of in vivo injury on the neuromuscular junction in healthy and dystrophic muscles.The Journal of physiology · 2013Article
- Clinical and Histologic Manifestations of a Novel Rectus Femoris Myotendinous Junction Injury in Rats.Muscles, ligaments and tendons journalArticle
- Time to recovery of sciatic function index after induced tibialis anterior strain in rats.Muscles, ligaments and tendons journalArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 3 institutions in 1 country.
Funding
Abstract
Most animal studies of muscle contractile function utilise the anterior or posterior crural muscle (dorsiflexors and plantarflexors, respectively). An advantage to using these muscles is that the common fibular and tibial nerves are readily accessible, while the small size of the crural muscles is a disadvantage. Working with small muscles not only makes some in vivo imaging and the muscle testing techniques more challenging, but also provides limited amounts of tissue to study. The purpose of this study was to describe a new animal muscle injury model in the quadriceps that results in a significant and reproducible loss of force. The thigh of Sprague Dawley rats (N=5) and C57BL/10 mice (N=5) was immobilised and the ankle was attached to a custom-made lever arm. The femoral nerve was stimulated using subcutaneous electrodes and injury was induced using 50 lengthening ("eccentric") contractions through a 70° arc of knee motion. This protocol produces a significant and reproducible injury, with comparable susceptibility to injury in the rats and mice. This novel model shows that the quadriceps muscle provides a means to study whole muscle contractility, injury, and recovery in vivo. In addition to the usual benefits of an in vivo model, the larger size of the quadriceps facilitates in vivo imaging and provides a significant increase in the amount of tissue available for histology and biochemistry studies. A controlled muscle injury in the quadriceps also allows one to study a muscle, with mixed fibre types, which is extremely relevant to gait in humans and quadruped models.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.