ArticleThe American journal of pathology2011
Heat shock protein 72 enhances autophagy as a protective mechanism in lipopolysaccharide-induced peritonitis in rats.
Article in The American journal of pathology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 48 citations in OpenAlex.
- Review
- Transcriptomic analysis identifies novel candidates in cardiorenal pathology mediated by chronic peritoneal dialysis.Scientific reports · 2023Article
- Autophagy in peritoneal fibrosis.Frontiers in physiology · 2023Review
- Role of the mTOR-autophagy-ER stress pathway in high fructose-induced metabolic-associated fatty liver disease.Acta pharmacologica Sinica · 2022Review
- Autophagy: Mechanisms and Therapeutic Potential of Flavonoids in Cancer.Biomolecules · 2021Review
- The Heat Shock Protein 70 Family of Chaperones Regulates All Phases of the Enterovirus A71 Life Cycle.Frontiers in microbiology · 2020Article
- ROS-induced HSP70 promotes cytoplasmic translocation of high-mobility group box 1b and stimulates antiviral autophagy in grass carp kidney cells.The Journal of biological chemistry · 2018Article
- Acetylation of HMGB1 by JNK1 Signaling Promotes LPS-Induced Peritoneal Mesothelial Cells Apoptosis.BioMed research international · 2018Article
- TG02 inhibits proteasome inhibitor-induced HSF1 serine 326 phosphorylation and heat shock response in multiple myeloma.Blood advances · 2017Article
- Far-infrared promotes burn wound healing by suppressing NLRP3 inflammasome caused by enhanced autophagy.Journal of molecular medicine (Berlin, Germany) · 2016Article
- HSP27 and 70 expression in thymic epithelial tumors and benign thymic alterations: diagnostic, prognostic and physiologic implications.Scientific reports · 2016Article
- A review of rodent models of peritoneal dialysis and its complications.International urology and nephrology · 2015Review
- Dynamic O-linked N-acetylglucosamine modification of proteins affects stress responses and survival of mesothelial cells exposed to peritoneal dialysis fluids.Journal of the American Society of Nephrology : JASN · 2014Article
- Regulation of autophagy by polyphenolic compounds as a potential therapeutic strategy for cancer.Cell death & disease · 2014Review
- Cell death and DAMPs in acute pancreatitis.Molecular medicine (Cambridge, Mass.) · 2014Review
- Management of a rapidly growing peritoneal dialysis population at the First Affiliated Hospital of Sun Yat-sen University.Peritoneal dialysis international : journal of the International Society for Peritoneal Dialysis · 2014Review
- Article
- Lipopolysaccharide (LPS)-induced autophagy is involved in the restriction of Escherichia coli in peritoneal mesothelial cells.BMC microbiology · 2013Article
- Autophagy: An Integral Component of the Mammalian Stress Response.Journal of biochemical and pharmacological research · 2013Article
- It's a cell-eat-cell world: autophagy and phagocytosis.The American journal of pathology · 2013Review
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Peritoneal dialysis-related peritonitis causes the denudation of mesothelial cells and, ultimately, membrane integrity alterations and peritoneal dysfunction. Because heat shock protein 72 (HSP72) confers protection against apoptosis and because autophagy mediates survival in response to cellular stresses, we examined whether autophagy contributes to HSP72-mediated cytoprotection in lipopolysaccharide (LPS)-induced peritonitis. Exposure of cultured peritoneal mesothelial cells to LPS resulted first in autophagy and later, apoptosis. Inhibition of autophagy by 3-methyladenine or Beclin-1 small-interfering RNA sensitized cells to apoptosis and abolished the antiapoptotic effect of HSP72, suggesting that autophagy activation acts as a prosurvival mechanism. Overexpression of HSP72 augmented autophagy through c-Jun N-terminal kinase (JNK) phosphorylation and Beclin-1 up-regulation. Suppression of JNK activity reversed HSP72-mediated Beclin-1 up-regulation and autophagy, indicating that HSP72-mediated autophagy is JNK dependent. In a rat model of LPS-associated peritonitis, autophagy occurred before apoptosis in peritoneum. Up-regulation of HSP72 by geranylgeranylacetone increased autophagy, inhibited apoptosis, and attenuated peritoneal injury, and these effects were blunted by down-regulation of HSP72 with quercetin. Additionally, blocking autophagy by chloroquine promoted apoptosis and aggravated LPS-associated peritoneal dysfunction. Thus, HSP72 protects peritoneum from LPS-induced mesothelial cells injury, at least in part by enhancing JNK activation-dependent autophagy and inhibiting apoptosis. These findings imply that HSP72 induction might be a potential therapy for peritonitis.
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