ArticleThe American journal of pathology2011
Increased expression of versican in the inflammatory response to UVB- and reactive oxygen species-induced skin tumorigenesis.
Article in The American journal of pathology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
20 citing papers in PubMed, 46 citations in OpenAlex.
- 8-Oxoguanine: A Lesion, an Epigenetic Mark, or a Molecular Signal?International journal of molecular sciences · 2025Review
- Transcriptomic responses of lung mesenchymal cells during pneumonia.JCI insight · 2025Article
- Photobiomodulation Increases M2-Type Polarization of Macrophages by Inhibiting Versican Production After Spinal Cord Injury.Molecular neurobiology · 2024Article
- Single cell RNA-sequencing of feline peripheral immune cells with V(D)J repertoire and cross species analysis of T lymphocytes.bioRxiv : the preprint server for biology · 2024Article
- Single cell RNA-sequencing of feline peripheral immune cells with V(D)J repertoire and cross species analysis of T lymphocytes.Frontiers in immunology · 2024Article
- Peptide location fingerprinting reveals modification-associated biomarker candidates of ageing in human tissue proteomes.Aging cell · 2021Article
- Long-term Effects of 222-nm ultraviolet radiation C Sterilizing Lamps on Mice Susceptible to Ultraviolet Radiation.Photochemistry and photobiology · 2020Article
- Inhibitors of DNA Glycosylases as Prospective Drugs.International journal of molecular sciences · 2020Review
- Versican-A Critical Extracellular Matrix Regulator of Immunity and Inflammation.Frontiers in immunology · 2020Review
- Deletion of miR-126a Promotes Hepatic Aging and Inflammation in a Mouse Model of Cholestasis.Molecular therapy. Nucleic acids · 2019Article
- Emerging Perspective: Role of Increased ROS and Redox Imbalance in Skin Carcinogenesis.Oxidative medicine and cellular longevity · 2019Review
- Gene networks in basal cell carcinoma of the eyelid, analyzed using gene expression profiling.Oncology letters · 2018Article
- Enhanced sensitivity of Neil1DNA repair · 2016Article
- A Case-Control Study of Involvement of Oxidative DNA Damage and Alteration of Antioxidant Defense System in Patients with Basal Cell Carcinoma: Modulation by Tumor Removal.Oxidative medicine and cellular longevity · 2016Article
- Proteoglycans in Normal and Healing Skin.Advances in wound care · 2015Article
- Inhibitory effects of dietary Spirulina platensis on UVB-induced skin inflammatory responses and carcinogenesis.The Journal of investigative dermatology · 2014Article
- Cancer and innate immune system interactions: translational potentials for cancer immunotherapy.Journal of immunotherapy (Hagerstown, Md. : 1997) · 2012Review
- Regulation of DNA glycosylases and their role in limiting disease.Free radical research · 2012Review
- Inflammation amplification by Versican: the first mediator.International journal of molecular sciences · 2012Article
- Versican modulates tumor-associated macrophage properties to stimulate mesothelioma growth.OncoimmunologyArticle
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Excessive exposure to UV radiation is a major risk factor for developing skin cancer. UV-induced reactive oxygen species (ROS) cause accumulation of DNA damage products such as 8-oxoguanine (8-oxoG) in the skin. We have previously shown that mice lacking the repair enzyme 8-oxoguanine glycosylase (Ogg1 knockout mice) are highly susceptible to skin cancer after long-term UVB exposure. To investigate the genes involved, we performed gene profiling of Ogg1 knockout mouse skin after UVB exposure. Among the up-regulated genes in UVB-treated Ogg1 knockout mice, inflammatory response pathway-related genes were most affected. The Vcan gene, which encodes the large extracellular matrix proteoglycan versican, was continuously up-regulated in UVB-treated Ogg1 knockout mice, suggesting that versican is a mediator of skin cancer development. We examined the expression pattern of versican in skin tumors from wild-type mice and UVB-treated Ogg1 knockout mice, and also analyzed 157 sun-related human skin tumors. Versican was strongly expressed in malignant skin tumors in both mice and humans, and especially in Ogg1 knockout mice. Additionally, infiltrating neutrophils strongly colocalized with versican in UVB-treated Ogg1 knockout mouse skin. These data demonstrate that inflammatory responses, particularly neutrophil infiltration and versican up-regulation, are closely involved in UVB/ROS-induced skin tumorigenesis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.