ArticleFungal genetics and biology : FG & B2011
Modulation of fungal sensitivity to staurosporine by targeting proteins identified by transcriptional profiling.
Article in Fungal genetics and biology : FG & B, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
14 citing papers in PubMed, 18 citations in OpenAlex.
- An ABC-B Transporter Helps ProtectJournal of fungi (Basel, Switzerland) · 2026Article
- Staurosporine as an Antifungal Agent.International journal of molecular sciences · 2025Review
- Do mitochondria use efflux pumps to protect their ribosomes from antibiotics?Microbiology (Reading, England) · 2023Article
- The Fungal Cell Death RegulatorJournal of fungi (Basel, Switzerland) · 2019Article
- Changes in the Biophysical Properties of the Cell Membrane Are Involved in the Response ofFrontiers in physiology · 2018Article
- Draft whole genome sequence of groundnut stem rot fungus Athelia rolfsii revealing genetic architect of its pathogenicity and virulence.Scientific reports · 2017Article
- Regulated Forms of Cell Death in Fungi.Frontiers in microbiology · 2017Review
- Transcription profiling of the Neurospora crassa response to a group of synthetic (thio)xanthones and a natural acetophenone.Genomics data · 2015Article
- Isolation and Characterization of the Colletotrichum acutatum ABC Transporter CaABC1.The plant pathology journal · 2014Article
- Activation of a TRP-like channel and intracellular Ca2+ dynamics during phospholipase-C-mediated cell death.Journal of cell science · 2014Article
- Extracellular calcium triggers unique transcriptional programs and modulates staurosporine-induced cell death inMicrobial cell (Graz, Austria) · 2014Article
- CZT-1 is a novel transcription factor controlling cell death and natural drug resistance in Neurospora crassa.G3 (Bethesda, Md.) · 2014Article
- The transcriptional response to nonself in the fungus Podospora anserina.G3 (Bethesda, Md.) · 2013Article
- High-efficiency liposomal encapsulation of a tyrosine kinase inhibitor leads to improved in vivo toxicity and tumor response profile.International journal of nanomedicine · 2013Article
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 2 countries.
Funding
Abstract
An analysis of the time-dependent genetic response to the death-inducer staurosporine was performed in Neurospora crassa by transcriptional profiling. Staurosporine induced two major genes encoding an ABC transporter and a protein with similarity to regulatory subunits of potassium channels. The transcriptional response is dependent on the activity of a novel transcription factor. Deletion mutants in differentially expressed genes displayed altered sensitivity to staurosporine, underscoring significant proteins involved in the response to the drug. A null-mutant of the ABC transporter (abc3) is extremely sensitive to staurosporine, accumulates more staurosporine than the wild type strain and is defective in energy-dependent export of the drug, indicating that the ABC3 protein is the first described staurosporine transporter. It was located in the plasma membrane by immunofluorescence microscopy. The combination of inhibitors of ABC transporters or of potassium channels with staurosporine leads to an enhanced activity against N. crassa and pathogenic fungi paving the way to the development of more potent and specific antifungals. Our results highlight the general use of transcriptional profiling for the identification of novel proteins involved in cell death and their potential use as drug targets.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.