Evidence map›Paper›PMID 22001159›Full record

ReviewExperimental neurology2012

Stress, depression and Parkinson's disease.

Ann M Hemmerle, James P Herman, Kim B Seroogy

Registry-linked trialAbstract readReview
In one paragraph

Review in Experimental neurology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05779137 (The Effect of Mindfulness-based Cognitive Therapy on Psychological Distress in People With Parkinson's Disease), which is not on this map. Cited by 105 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
105citing papers in PubMed, 4 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05779137 naactive not recruitingnot on this mapstarted 2023, after this paper: background citation

The Effect of Mindfulness-based Cognitive Therapy on Psychological Distress in People With Parkinson's Disease

TypeinterventionalSponsorRadboud University Medical CenterRan2023 to 2026Enrolled174ConditionsParkinson's DiseaseArmsMBCT
3 · Its place in the literature

Who cites it

105 citing papers in PubMed, 4 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Lifestyle medicine for neuroprotection: evidence and implementation in Asian contexts.Journal of neural transmission (Vienna, Austria : 1996) · 2026
    Review
  6. Article
  7. Perspective: Depression in Persons with Parkinson's Disease.Movement disorders : official journal of the Movement Disorder Society · 2026
    Review
  8. Review
  9. Article
  10. Review
  11. Temperature fluctuations and genetic influences on Parkinson's disease: a comprehensive analysis of temperature variability and time spent outdoors in the United States (1999-2023).Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026
    Article
  12. Article
  13. Article
  14. Review
  15. Article
  16. Review
  17. Review
  18. Article
  19. Article
  20. Article

45 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Ann M HemmerleDepartment of Neurology, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA.
James P Herman
Kim B Seroogy

Funding

STN Deep Brain Stimulation and NeuroprotectionP50NS058830 · NINDS · UNIVERSITY OF CINCINNATI · PI COLLIER, TIMOTHY J. · 2009 to 2015
$5.9M
Stress-Induced Depression and Parkinsonian SymptomologyR01NS060114 · NINDS · UNIVERSITY OF CINCINNATI · PI SEROOGY, KIM B · 2008 to 2012
$1.7M
NINDS NIH HHS NS058830NINDS NIH HHS NS060114NINDS NIH HHS P50 NS058830NINDS NIH HHS R01 NS060114
6 · The paper itself

Abstract

In this review, we focus on the relationship among Parkinson's disease (PD), stress and depression. Parkinson's disease patients have a high risk of developing depression, and it is possible that stress contributes to the development of both pathologies. Stress dysfunction may have a role in the etiology of preclinical non-motor symptoms of PD (such as depression) and, later in the course of the disease, may worsen motor symptoms. However, relatively few studies have examined stress or depression and the injured nigrostriatal system. This review discusses the effects of stress on neurodegeneration and depression, and their association with the symptoms and progression of PD.

Indexed as

AnimalsCorpus StriatumDepressive DisorderDisease Models, AnimalDisease ProgressionHumansNerve DegenerationParkinson DiseaseStress, Psychological

Identifiers

PMID22001159
PMCPMC3268878

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.