Evidence map›Paper›PMID 22000952›Full record

ReviewCurrent opinion in neurobiology2012

Posttranslational regulation of AMPA receptor trafficking and function.

Wei Lu, Katherine W Roche

Abstract readReview
In one paragraph

Review in Current opinion in neurobiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 112 papers.

0numbers the graph read from it
0cells of the map it votes in
112citing papers in PubMed
6.3field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

112 citing papers in PubMed, 195 citations in OpenAlex.

  1. Review
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  8. Ubiquitination of the GluA1 Subunit of AMPA Receptors Is Required for Synaptic Plasticity, Memory, and Cognitive Flexibility.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023
    Article
  9. Article
  10. Article
  11. Article
  12. Review
  13. Review
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  15. Review
  16. Article
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  18. Review
  19. AMPA Receptor Function in Hypothalamic Synapses.Frontiers in synaptic neuroscience · 2022
    Review
  20. Article

52 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Wei LuDepartment of Cellular and Molecular Pharmacology, University of California, San Francisco, CA 94143, USA. luwei@cmp.ucsf.edu
Katherine W Roche
National Institutes of Health · US

Funding

Subunit-Specific Regulation Of Glutamate ReceptorsZIANS002994 · NINDS · NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE · PI ROCHE, KATHERINE · 2009 to 2025
$30.0M
The regulation of synaptic transmission and neural circuit functionZIANS003136 · NINDS · NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE · PI LU, WEI · 2012 to 2025
$27.0M
Role of the Loop1 Domain in AMPA Receptor TraffickingK99MH090239 · NIMH · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI LU, WEI · 2011 to 2011
$54k
Intramural NIH HHS ZIA NS002994NIMH NIH HHS K99 MH090239NIMH NIH HHS K99 MH090239-01A1
6 · The paper itself

Abstract

In the mammalian central nervous system, the majority of fast excitatory synaptic transmission is mediated by glutamate acting on AMPA-type ionotropic glutamate receptors. The abundance of AMPA receptors at the synapse can be modulated through receptor trafficking, which dynamically regulates many fundamental brain functions, including learning and memory. Reversible posttranslational modifications, including phosphorylation, palmitoylation and ubiquitination of AMPA receptor subunits are important regulatory mechanisms for controlling synaptic AMPA receptor expression and function. In this review, we highlight recent advances in the study of AMPA receptor posttranslational modifications and discuss how these modifications regulate AMPA receptor trafficking and function at synapses.

Indexed as

AnimalsModels, BiologicalProtein BiosynthesisProtein TransportReceptors, AMPASynapsesReceptors, AMPA

Identifiers

PMID22000952
PMCPMC3279598
OpenAlexW2086494545

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.