ReviewTransplantation reviews (Orlando, Fla.)2012
Emerging role of innate immunity in organ transplantation: part I: evolution of innate immunity and oxidative allograft injury.
Review in Transplantation reviews (Orlando, Fla.), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
26 citing papers in PubMed, 68 citations in OpenAlex.
- Antioxidant Cerium Oxide Nanoparticle Coatings Impart Immunomodulatory Effects by Suppressing Antigen-Specific Cytotoxic T Cell Activation.Journal of biomedical materials research. Part A · 2025Article
- Ischemia-free liver transplantation improves long-term outcomes in a 5-year follow-up study.JHEP reports : innovation in hepatology · 2025Article
- Thrombotic Microangiopathy: A Devastating Complication After Lung Transplantation.Transplantation direct · 2025Article
- Regulated cell death and DAMPs as biomarkers and therapeutic targets in normothermic perfusion of transplant organs. Part 2: implementation strategies.Frontiers in transplantation · 2025Review
- Regulated cell death and DAMPs as biomarkers and therapeutic targets in normothermic perfusion of transplant organs. Part 1: their emergence from injuries to the donor organ.Frontiers in transplantation · 2025Review
- An untargeted metabolomics approach to study changes of the medium during human cornea culture.Metabolomics : Official journal of the Metabolomic Society · 2024Article
- The conclusion of reducing acute rejection after liver transplantation by machine perfusion should be extrapolated with caution.Hepatobiliary surgery and nutrition · 2023Article
- Typical and atypical properties of peripheral nerve allografts enable novel strategies to repair segmental-loss injuries.Journal of neuroinflammation · 2022Review
- Impact of Machine Perfusion on the Immune Response After Liver Transplantation - A Primary Treatment or Just a Delivery Tool.Frontiers in immunology · 2022Review
- Viability Assessment in Liver Transplantation-What Is the Impact of Dynamic Organ Preservation?Biomedicines · 2021Review
- Coding transcriptome analyses reveal altered functions underlying immunotolerance of PEG-fused rat sciatic nerve allografts.Journal of neuroinflammation · 2020Article
- Vascular Signaling in Allogenic Solid Organ Transplantation - The Role of Endothelial Cells.Frontiers in physiology · 2020Review
- FTY720 Regulates Mitochondria Biogenesis in Dendritic Cells to Prevent Kidney Ischemic Reperfusion Injury.Frontiers in immunology · 2020Article
- Machine perfusion strategies in liver transplantation.Hepatobiliary surgery and nutrition · 2019Review
- High-density lipoprotein ameliorates palmitic acid-induced lipotoxicity and oxidative dysfunction in H9c2 cardiomyoblast cells via ROS suppression.Nutrition & metabolism · 2019Article
- Allograft dendritic cell p40 homodimers activate donor-reactive memory CD8+ T cells.JCI insight · 2018Article
- SIRT3 a Major Player in Attenuation of Hepatic Ischemia-Reperfusion Injury by Reducing ROS via Its Downstream Mediators: SOD2, CYP-D, and HIF-1Oxidative medicine and cellular longevity · 2018Review
- Toll-Like Receptor Stimulation by MicroRNAs in Acute Graft-vs.-Host Disease.Frontiers in immunology · 2018Review
- Effect of FTY720 (fingolimod) on graft survival in renal transplant recipients: a systematic review protocol.BMJ open · 2016Article
- Graft microvascular disease in solid organ transplantation.Journal of molecular medicine (Berlin, Germany) · 2014Review
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Abstract
The innate immune system is an evolutionarily highly conserved first rapid line of host defense against tissue injury and consists of a whole family of mobile and sessile cells such as antigen-presenting cells, innate lymphocytes, neutrophils, and vascular cells-dendritic cells representing the bridge to development of an adaptive immune response. The system depends on molecules collectively known as pattern recognition receptors to survey the extracellular space and the cytoplasm for the presence of exogenous pathogen-associated molecular patterns derived from microorganisms as well as damage-associated molecular patterns derived from endogenous tissue injury. Among various pattern recognition receptors, Toll-like receptors play central roles in sensing tissue damage and activating the innate immune system following any injury including postischemic reperfusion injury. This part I of a review focuses on reactive oxygen species-mediated reperfusion injury in terms of a canonical injury to every solid allograft that metamorphoses it into an acutely inflamed organ. Sources and mechanisms of reactive oxygen species production during postischemic reperfusion injury are reviewed by stressing a role of reactive oxygen species-producing enzyme systems as well as differentiating between reactive oxygen species production in donor-derived vascular cells and recipient-derived neutrophils. Finally, a potential role of hypoxia-sensing enzyme systems in the generation of reactive oxygen species is being discussed as an evolutionary principle and the critical cause of oxidative injury to allografts during reperfusion in the recipient.
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