PARG: a macrodomain in disguise.

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

Who cites it

7 citing papers in PubMed.

1. ADP-ribosylhydrolases: from DNA damage repair to COVID-19.Journal of Zhejiang University. Science. B · 2021
   Review
2. Emerging roles of eraser enzymes in the dynamic control of protein ADP-ribosylation.Nature communications · 2019
   Review
3. Transition-state analysis of 2-O-acetyl-ADP-ribose hydrolysis by human macrodomain 1.ACS chemical biology · 2014
   Article
4. Host cell poly(ADP-ribose) glycohydrolase is crucial for Trypanosoma cruzi infection cycle.PloS one · 2013
   Article
5. Quantitative proteomics profiling of the poly(ADP-ribose)-related response to genotoxic stress.Nucleic acids research · 2012
   Article
6. New readers and interpretations of poly(ADP-ribosyl)ation.Trends in biochemical sciences · 2012
   Review
7. Structures of the human poly (ADP-ribose) glycohydrolase catalytic domain confirm catalytic mechanism and explain inhibition by ADP-HPD derivatives.PloS one · 2012
   Article

Corrections and comments

• Comment on
  The structure and catalytic mechanism of a poly(ADP-ribose) glycohydrolase.2011

Authors and funding

3 authors.

Funding

No grant is acknowledged in the PubMed record.

Abstract