ArticleAnnals of epidemiology2011
Have secular changes in perinatal risk factors contributed to the recent autism prevalence increase? Development and application of a mathematical assessment model.
Article in Annals of epidemiology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
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Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 59 citations in OpenAlex.
- Effect of cesarean section on the risk of autism spectrum disorders/attention deficit hyperactivity disorder in offspring: a meta-analysis.Archives of gynecology and obstetrics · 2024Pooled it
- The Prevalence of Autism Spectrum Disorders in the Russian Federation: A Retrospective Study.Consortium psychiatricum · 2022Article
- Perinatal and Obstetric Predictors for Autism Spectrum Disorder.Journal of autism and developmental disorders · 2021Article
- National and State Estimates of Adults with Autism Spectrum Disorder.Journal of autism and developmental disorders · 2020Article
- Incomplete Gestation has an Impact on Cognitive Abilities in Autism Spectrum Disorder.Journal of autism and developmental disorders · 2019Article
- Maternal and Paternal Infertility Disorders and Treatments and Autism Spectrum Disorder: Findings from the Study to Explore Early Development.Journal of autism and developmental disorders · 2017Article
- Autism spectrum disorder: updated prevalence and comparison of two birth cohorts in a nationally representative Australian sample.BMJ open · 2017Article
- Infant and dyadic assessment in early community-based screening for autism spectrum disorder with the PREAUT grid.PloS one · 2017Article
- Hypothesis on supine sleep, sudden infant death syndrome reduction and association with increasing autism incidence.World journal of clinical pediatrics · 2016Article
- Population impact of preterm birth and low birth weight on developmental disabilities in US children.Annals of epidemiology · 2016Article
- Comparison of Perinatal Risk Factors Associated with Autism Spectrum Disorder (ASD), Intellectual Disability (ID), and Co-occurring ASD and ID.Journal of autism and developmental disorders · 2015Article
- Reply: CDC analysis of ICSI/autism: association is not causation.Human reproduction (Oxford, England) · 2015Article
- Changes in prevalence of autism spectrum disorders in 2001-2011: findings from the Stockholm youth cohort.Journal of autism and developmental disorders · 2015Article
- Association of assisted reproductive technology (ART) treatment and parental infertility diagnosis with autism in ART-conceived children.Human reproduction (Oxford, England) · 2015Observational
- Article
- Prenatal SSRI use and offspring with autism spectrum disorder or developmental delay.Pediatrics · 2014Article
- Population attributable fractions for three perinatal risk factors for autism spectrum disorders, 2002 and 2008 autism and developmental disabilities monitoring network.Annals of epidemiology · 2014Article
- Recent increase in autism and ADHD: true or inflated?Journal of Korean medical science · 2013Article
- Genomics and autism spectrum disorder.Journal of nursing scholarship : an official publication of Sigma Theta Tau International Honor Society of Nursing · 2013Review
- Autism spectrum disorder in children born preterm-role of exposure to perinatal inflammation.Frontiers in neuroscience · 2013Article
Corrections and comments
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Authors and funding
11 authors at 7 institutions in 1 country.
Funding
Abstract
backgroundA 57% increase in the U.S. prevalence of autism spectrum disorders (ASD) for 8-year-old children born in 1994 versus 1998 was recently reported.
methodsTo quantify the possible contributions of given risk/predictive factors on the recent ASD prevalence increase, we formulated a mathematical model based on the baseline risk factor prevalence (RFP), the proportionate change in RFP (cRFP), and the magnitude of the association between the risk factor and ASD [estimated relative risk (RR)]. We applied this model to several pregnancy-related factors (preterm, very preterm, low and very low birth weight, multiple birth, cesarean delivery, breech presentation, and assisted reproductive technology use). RFP and cRFP estimates for each factor were obtained from U.S. population-based surveillance datasets. Estimated RRs were obtained from a series of systematic literature reviews.
resultsWe estimate that each risk factor examined, alone or in various combinations, accounted for a very small proportion (<1%) of the ASD increase. Additionally, hypothetical scenarios indicate RFP, cRFP, and RR all need to be sizable for a risk factor to appreciably influence ASD prevalence.
conclusionsThus, although various pregnancy factors have been found to be associated with ASDs, the contribution of many of these factors to the recently observed ASD increase is likely minimal.
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Registered trials
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