Trial reportBrain research2011
The hippocampus is functionally connected to the striatum and orbitofrontal cortex during context dependent decision making.
Trial report in Brain research, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed.
- Hippocampal and ventral medial prefrontal activation during retrieval-mediated learning supports novel inference.Neuron · 2012Trial
- Hippocampus Functional Connectivity, Impulsivity, and Subsequent Substance Use.Journal of cellular neuroscience · 2025Article
- Functional ultrasound imaging and prewhitening analysis reveal MK-801-induced disruption of brain network connectivity.Frontiers in pharmacology · 2025Article
- Self-regulation training generalizability using the regulation of craving task. An fMRI study.Frontiers in psychology · 2024Article
- Accounting for multiscale processing in adaptive real-world decision-making via the hippocampus.Frontiers in neuroscience · 2023Review
- Regional Differences in S-Nitrosylation in the Cortex, Striatum, and Hippocampus of Juvenile Male Mice.Journal of molecular neuroscience : MN · 2021Article
- Evidence for a gradient within the medial temporal lobes for flexible retrieval under hierarchical task rules.Hippocampus · 2021Article
- Adolescent substance use and functional connectivity between the ventral striatum and hippocampus.Behavioural brain research · 2020Article
- Cortico-Striatal Oscillations Are Correlated to Motor Activity Levels in Both Physiological and Parkinsonian Conditions.Frontiers in systems neuroscience · 2020Article
- Interactions between monoamine oxidase A rs1137070 and smoking on brain structure and function in male smokers.The European journal of neuroscience · 2019Article
- Predictability matters: role of the hippocampus and prefrontal cortex in disambiguation of overlapping sequences.Learning & memory (Cold Spring Harbor, N.Y.) · 2018Article
- Inside the Developing Brain to Understand Teen Behavior From Rat Models: Metabolic, Structural, and Functional-Connectivity Alterations Among Limbic Structures Across Three Pre-adolescent Stages.Frontiers in behavioral neuroscience · 2018Article
- Reactive Neuroblastosis in Huntington's Disease: A Putative Therapeutic Target for Striatal Regeneration in the Adult Brain.Frontiers in cellular neuroscience · 2018Article
- The Complex Nature of Hippocampal-Striatal Interactions in Spatial Navigation.Frontiers in human neuroscience · 2018Article
- Reinforcement Learning and Episodic Memory in Humans and Animals: An Integrative Framework.Annual review of psychology · 2017Review
- Striatum on the anxiety map: Small detours into adolescence.Brain research · 2017Review
- Noninvasive functional and anatomical imaging of the human medial temporal lobe.Cold Spring Harbor perspectives in biology · 2015Review
- Brain networks for exploration decisions utilizing distinct modeled information types during contextual learning.Neuron · 2014Article
- Long-term memory guidance of visuospatial attention in a change-detection paradigm.Frontiers in psychology · 2014Article
- Role of the hippocampus and orbitofrontal cortex during the disambiguation of social cues in working memory.Cognitive, affective & behavioral neuroscience · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
Many of our everyday actions are only appropriate in certain situations and selecting the appropriate behavior requires that we use current context and previous experience to guide our decisions. The current study examined hippocampal functional connectivity with prefrontal and striatal regions during a task that required participants to make decisions based on the contextual retrieval of overlapping sequential representations. Participants learned four sequences comprised of six faces each. An overlapping condition was created by having two sequences with two identical faces as the middle images. A non-overlapping condition contained two sequences that did not share any faces between them. Hippocampal functional connectivity was assessed during the presentation period and at the critical choice, where participants had to make a contextually dependent decision. The left hippocampus showed significantly increased functional connectivity with dorsal and ventral striatum and anterior cingulate cortex during the presentation period of the overlapping compared to the non-overlapping condition after participants knew the sequences. At the critical choice point of the overlapping condition, the left hippocampus showed stronger functional connectivity with the orbitofrontal cortex. These functional connectivity results suggest that the hippocampus may play a role in decision making by predicting the possibilities of what might come next, allowing orbitofrontal and striatal regions to evaluate the expected choice options in order to make the correct action at the choice point.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.