ArticleJournal of psychosomatic research2011
Social support and clinical outcomes during antiviral therapy for chronic hepatitis C.
Article in Journal of psychosomatic research, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
7 citing papers in PubMed, 31 citations in OpenAlex.
- A Systematic Comparison of African American and Non-African American Patients on Psychosocial Aspects of Hepatitis C Infection.Journal of religion and health · 2018Trial
- Examination of using alcohol to cope, depressive symptoms, and perceived social support in persons with HIV and Hepatitis C.AIDS care · 2020Article
- A Descriptive Analysis of a Community Clinic Providing Hepatitis C Treatment to Poor and Uninsured Patients.Journal of community health · 2018Article
- Conceptual framework for outcomes research studies of hepatitis C: an analytical review.Infection and drug resistance · 2016Review
- Formal hepatitis C education enhances HCV care coordination, expedites HCV treatment and improves antiviral response.Liver international : official journal of the International Association for the Study of the Liver · 2013Article
- Neuropsychiatric and psychosocial issues of patients with hepatitis C infection: a selective literature review.Hepatitis monthly · 2013Article
- Reliability and validity of a self-efficacy instrument for hepatitis C antiviral treatment regimens.Journal of viral hepatitis · 2012Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
objectiveTo determine if social support (SS) is associated with clinical outcomes during antiviral therapy for chronic hepatitis C virus (HCV).
methodsData from 394 patients who participated in the prospective, longitudinal VIRAHEP-C study were examined. VIRAHEP-C enrolled 401 adults with HCV to evaluate factors associated with antiviral treatment response. Perceived SS was measured using the Medical Outcome Study Social Support Survey (MOS-SSS) at baseline and treatment week 24. Scores were calculated as a continuous variable ranging from 0% to 100% with higher scores indicating greater support. Two SS variables were created: (1) baseline SS (BL-SS) and (2) change in SS from baseline to treatment week 24 (CH-SS). The primary endpoint was sustained virological response (SVR) six months post-treatment. Intermediate outcomes included: symptom-reporting; virological response at treatment week 24; medication adherence; neuropsychiatric adverse events; and dose reductions and premature medication discontinuation. The relative risk of each outcome was estimated using modified Poisson regression models or linear mixed models.
resultsBL-SS was relatively high (mean=79%). Overall, SS declined from baseline to treatment week 24 (median change: -1.3%; p<.01). Neither BL-SS nor CH-SS was associated with SVR. However, BL-SS was associated with multiple symptoms (fatigue, headache, irritability, aches/pains) during treatment, even after adjusting for baseline depression, which was significantly associated with symptom-reporting.
conclusionsSS was not directly associated with efficacy measures, such as SVR. However, baseline SS predicted an increase in symptomatology over the course of antiviral therapy. Baseline depression was also significantly associated with symptom-reporting.
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Registered trials
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