ArticleThe Journal of asthma : official journal of the Association for the Care of Asthma2011
Extracellular cyclophilin levels associate with parameters of asthma in phenotypic clusters.
Article in The Journal of asthma : official journal of the Association for the Care of Asthma, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
10 citing papers in PubMed, 29 citations in OpenAlex.
- Neutrophil Heterogeneity in Airway Inflammatory Diseases.Inflammation · 2025Review
- Non-Immunosuppressive Cyclophilin Inhibitors.Angewandte Chemie (International ed. in English) · 2022Review
- Neutrophils and Asthma.Diagnostics (Basel, Switzerland) · 2022Review
- Cyclophilin A Plays Potential Roles in a Rat Model of Asthma and Suppression of Immune Response.Journal of asthma and allergy · 2021Article
- Pediatric asthma comprises different phenotypic clusters with unique nasal microbiotas.Microbiome · 2018Article
- Sex differences in the association between neck circumference and asthma.Pediatric pulmonology · 2016Observational
- Integrating microbial and host transcriptomics to characterize asthma-associated microbial communities.BMC medical genomics · 2015Article
- The roles of CD147 and/or cyclophilin A in kidney diseases.Mediators of inflammation · 2014Review
- The human secretome atlas initiative: implications in health and disease conditions.Biochimica et biophysica acta · 2013Article
- Cyclophilin A: a key player for human disease.Cell death & disease · 2013Review
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
objectiveLeukocyte persistence during chronic (quiescent) phases of asthma is a major hallmark of the disease. The mechanisms regulating these persistent leukocyte populations are not clearly understood. An alternative family of chemoattracting proteins, cyclophilins (Cyps), has recently been shown to contribute to leukocyte recruitment in animal models of allergic asthma. The goals of this study were to determine whether Cyps are present in asthma patients during the chronic phase of the disease and to investigate whether levels of Cyps associate with clinical parameters of disease severity.
methodsNasal wash samples from an urban cohort of 137 patients of age 6-20 years with physician-diagnosed asthma were examined for the presence of cyclophilin A (CypA), cyclophilin B (CypB), as well as several other classical chemokines. Linear, logistic, or ordinal regressions were performed to identify associations between Cyps, chemokines, and clinical parameters of asthma. The asthma cohort was further divided into previously established phenotypic clusters (cluster 1: n = 55; cluster 2: n = 31; and cluster 3: n = 51) and examined for associations.
resultsLevels of CypB in the asthma group were highly elevated compared to nonasthmatic controls, while a slight increase in Monocyte Chemotactic Protein-1 (MCP-1) was also observed. CypA and MCP-1 were associated with levels of eosinophil cationic protein (ECP; a marker of eosinophil activation). Cluster-specific associations were found for CypA and CypB and clinical asthma parameters [e.g. forced expiratory volume in 1 second (FEV(1)) and ECP].
conclusionsCyps are present in nasal wash samples of asthma patients and may be a novel biomarker for clinical parameters of asthma severity.
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