SynthesisBMC genomics2011
Meta-analysis and genome-wide interpretation of genetic susceptibility to drug addiction.
Synthesis in BMC genomics, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 2 syntheses or guidelines pooled it, 37 citations in OpenAlex.
- The Etiologic, Theory-Based, Ontogenetic Hierarchical Framework of Alcohol Use Disorder: A Translational Systematic Review of Reviews.Psychological bulletin · 2021Pooled it
- Exploring drug-target interaction networks of illicit drugs.BMC genomics · 2013Pooled it
- Understanding the Mechanisms of Action and Effects of Drugs of Abuse.Molecules (Basel, Switzerland) · 2023Review
- Biomarkers of the Endocannabinoid System in Substance Use Disorders.Biomolecules · 2022Review
- Biotechnical development of genetic addiction risk score (GARS) and selective evidence for inclusion of polymorphic allelic risk in substance use disorder (SUD).Journal of systems and integrative neuroscience · 2020Article
- Prospects for finding the mechanisms of sex differences in addiction with human and model organism genetic analysis.Genes, brain, and behavior · 2020Review
- In Search of Reward Deficiency Syndrome (RDS)-free Controls: The "Holy Grail" in Genetic Addiction Risk Testing.Current psychopharmacology · 2020Article
- "I don't have to know why it snows, I just have to shovel it!": Addiction Recovery, Genetic Frameworks, and Biological Citizenship.BioSocieties · 2017Article
- The genetic epidemiology of substance use disorder: A review.Drug and alcohol dependence · 2017Review
- Genetic variation in FAAH is associated with cannabis use disorders in a young adult sample of Mexican Americans.Drug and alcohol dependence · 2016Article
- An Inventory of Methods for the Assessment of Additive Increased Addictiveness of Tobacco Products.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2016Review
- A genome-wide investigation of food addiction.Obesity (Silver Spring, Md.) · 2016Article
- Variations in opioid receptor genes in neonatal abstinence syndrome.Drug and alcohol dependence · 2015Article
- Addiction-related genes in gambling disorders: new insights from parallel human and pre-clinical models.Molecular psychiatry · 2015Article
- The media and behavioral genetics: Alternatives coexisting with addiction genetics.Science, technology & human values · 2015Article
- A review of pharmacogenetic studies of substance-related disorders.Drug and alcohol dependence · 2015Review
- Unwarranted optimism in media portrayals of genetic research on addiction overshadows critical ethical and social concerns.Journal of health communication · 2015Article
- Genome-wide scans of genetic variants for psychophysiological endophenotypes: a methodological overview.Psychophysiology · 2014Review
- Genetic Addiction Risk Score (GARS): molecular neurogenetic evidence for predisposition to Reward Deficiency Syndrome (RDS).Molecular neurobiology · 2014Article
- Heritability and molecular genetic basis of electrodermal activity: a genome-wide association study.Psychophysiology · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
Abstract
backgroundClassical genetic studies provide strong evidence for heritable contributions to susceptibility to developing dependence on addictive substances. Candidate gene and genome-wide association studies (GWAS) have sought genes, chromosomal regions and allelic variants likely to contribute to susceptibility to drug addiction.
resultsHere, we performed a meta-analysis of addiction candidate gene association studies and GWAS to investigate possible functional mechanisms associated with addiction susceptibility. From meta-data retrieved from 212 publications on candidate gene association studies and 5 GWAS reports, we linked a total of 843 haplotypes to addiction susceptibility. We mapped the SNPs in these haplotypes to functional and regulatory elements in the genome and estimated the magnitude of the contributions of different molecular mechanisms to their effects on addiction susceptibility. In addition to SNPs in coding regions, these data suggest that haplotypes in gene regulatory regions may also contribute to addiction susceptibility. When we compared the lists of genes identified by association studies and those identified by molecular biological studies of drug-regulated genes, we observed significantly higher participation in the same gene interaction networks than expected by chance, despite little overlap between the two gene lists.
conclusionsThese results appear to offer new insights into the genetic factors underlying drug addiction.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.