ArticleBMC genomics2011
The human genome: a multifractal analysis.
Article in BMC genomics, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 54 citations in OpenAlex.
- Enlarging viral mutation estimation: a view from the distribution of mutation rates.Microbiology (Reading, England) · 2026Article
- Microbial characterization based on multifractal analysis of metagenomes.Frontiers in cellular and infection microbiology · 2023Article
- Nucleotide spacing distribution analysis for human genome.Mammalian genome : official journal of the International Mammalian Genome Society · 2021Article
- Fractal genomics of SOD1 evolution.Immunogenetics · 2020Article
- Structure, clustering and functional insights of repeats configurations in the upstream promoter region of the human coding genes.BMC genomics · 2018Article
- Review
- Reliable Multi-Fractal Characterization of Weighted Complex Networks: Algorithms and Implications.Scientific reports · 2017Article
- Complex multifractal nature in Mycobacterium tuberculosis genome.Scientific reports · 2017Article
- Additive methods for genomic signatures.BMC bioinformatics · 2016Article
- On the organization of human T-cell receptor loci: log-periodic distribution of T-cell receptor gene segments.Journal of the Royal Society, Interface · 2016Review
- The potential role of Alu Y in the development of resistance to SN38 (Irinotecan) or oxaliplatin in colorectal cancer.BMC genomics · 2015Article
- Pattern matching through Chaos Game Representation: bridging numerical and discrete data structures for biological sequence analysis.Algorithms for molecular biology : AMB · 2012Article
Corrections and comments
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Authors and funding
11 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSeveral studies have shown that genomes can be studied via a multifractal formalism. Recently, we used a multifractal approach to study the genetic information content of the Caenorhabditis elegans genome. Here we investigate the possibility that the human genome shows a similar behavior to that observed in the nematode.
resultsWe report here multifractality in the human genome sequence. This behavior correlates strongly on the presence of Alu elements and to a lesser extent on CpG islands and (G+C) content. In contrast, no or low relationship was found for LINE, MIR, MER, LTRs elements and DNA regions poor in genetic information. Gene function, cluster of orthologous genes, metabolic pathways, and exons tended to increase their frequencies with ranges of multifractality and large gene families were located in genomic regions with varied multifractality. Additionally, a multifractal map and classification for human chromosomes are proposed.
conclusionsBased on these findings, we propose a descriptive non-linear model for the structure of the human genome, with some biological implications. This model reveals 1) a multifractal regionalization where many regions coexist that are far from equilibrium and 2) this non-linear organization has significant molecular and medical genetic implications for understanding the role of Alu elements in genome stability and structure of the human genome. Given the role of Alu sequences in gene regulation, genetic diseases, human genetic diversity, adaptation and phylogenetic analyses, these quantifications are especially useful.
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