ArticlePloS one2011
Major population expansion of East Asians began before neolithic time: evidence of mtDNA genomes.
Article in PloS one, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
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39 citing papers in PubMed, 81 citations in OpenAlex.
- Maternal genetic structure and population affinities of the Sichuan Han Chinese based on whole mitochondrial genomes.BMC genomics · 2026Article
- Introgressed mitochondrial fragments from archaic hominins alter nuclear genome function in modern humans.Science advances · 2026Article
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- The genetic history around the southeastern Mongolian Plateau traces Neolithic cultural diffusions in northern East Asia.Innovation (Cambridge (Mass.)) · 2026Article
- Sequencing and characterizing human mitochondrial genomes in the biobank-based genomic research paradigm.Science China. Life sciences · 2025Review
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- Mitochondrial DNA Genomes Reveal Relaxed Purifying Selection During Human Population Expansion after the Last Glacial Maximum.Molecular biology and evolution · 2024Article
- Mitogenomics of the Koryaks and Evens of the northern coast of the Sea of Okhotsk.Journal of human genetics · 2023Article
- Diversity and distribution of mitochondrial DNA in non-Austronesian-speaking Taiwanese individuals.Human genome variation · 2023Article
- Mitogenomics of modern Mongolic-speaking populations.Molecular genetics and genomics : MGG · 2022Article
- Genetic Diversity Analysis of the Chinese Daur Ethnic Group in Heilongjiang Province by Complete Mitochondrial Genome Sequencing.Frontiers in genetics · 2022Article
- Ancient genomics reveals tripartite origins of Japanese populations.Science advances · 2021Article
- Mitochondrial DNA haplogroup M7 confers a reduced risk of colorectal cancer in a Han population from northern China.Journal of cellular and molecular medicine · 2021Article
- A Mitochondrial DNA Variant Elevates the Risk of Gallstone Disease by Altering Mitochondrial Function.Cellular and molecular gastroenterology and hepatology · 2021Article
- Genetic legacy of cultures indigenous to the Northeast Asian coast in mitochondrial genomes of nearly extinct maritime tribes.BMC evolutionary biology · 2020Article
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- Ancient DNA Evidence from China Reveals the Expansion of Pacific Dogs.Molecular biology and evolution · 2020Article
- The Rare Variant rs35356162 inFrontiers in oncology · 2020Article
- Evidence of Neutral Evolution of Mitochondrial DNA in Human Hepatocellular Carcinoma.Genome biology and evolution · 2019Article
- MtDNA polymorphism analyses in the Chinese Mongolian group: Efficiency evaluation and further matrilineal genetic structure exploration.Molecular genetics & genomic medicine · 2019Article
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
It is a major question in archaeology and anthropology whether human populations started to grow primarily after the advent of agriculture, i.e., the Neolithic time, especially in East Asia, which was one of the centers of ancient agricultural civilization. To answer this question requires an accurate estimation of the time of lineage expansion as well as that of population expansion in a population sample without ascertainment bias. In this study, we analyzed all available mtDNA genomes of East Asians ascertained by random sampling, a total of 367 complete mtDNA sequences generated by the 1000 Genome Project, including 249 Chinese (CHB, CHD, and CHS) and 118 Japanese (JPT). We found that major mtDNA lineages underwent expansions, all of which, except for two JPT-specific lineages, including D4, D4b2b, D4a, D4j, D5a2a, A, N9a, F1a1'4, F2, B4, B4a, G2a1 and M7b1'2'4, occurred before 10 kya, i.e., before the Neolithic time (symbolized by Dadiwan Culture at 7.9 kya) in East Asia. Consistent to this observation, the further analysis showed that the population expansion in East Asia started at 13 kya and lasted until 4 kya. The results suggest that the population growth in East Asia constituted a need for the introduction of agriculture and might be one of the driving forces that led to the further development of agriculture.
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