Trial reportPloS one2011
Preferential inhibition of frontal-to-parietal feedback connectivity is a neurophysiologic correlate of general anesthesia in surgical patients.
Trial report in PloS one, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 122 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
122 citing papers in PubMed, 1 synthesis or guideline pooled it, 216 citations in OpenAlex.
- How perceptual learning rewires brain connectivity: lessons from the visual system in a top-down perspective.Frontiers in neural circuits · 2025Pooled it
- The influence of induction speed on the frontal (processed) EEG.Scientific reports · 2020Trial
- Directional connectivity between frontal and posterior brain regions is altered with increasing concentrations of propofol.PloS one · 2014Trial
- Electroencephalogram signatures of loss and recovery of consciousness from propofol.Proceedings of the National Academy of Sciences of the United States of America · 2013Trial
- Event-related functional magnetic resonance imaging of a low dose of dexmedetomidine that impairs long-term memory.Anesthesiology · 2012Trial
- Connectivity changes underlying spectral EEG changes during propofol-induced loss of consciousness.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Trial
- Cellular and Microcircuit Mechanisms of Anesthetic Disruption of Conscious-State Organization.Cells · 2026Review
- Characteristics of electroencephalographic changes induced by different hypnotics in elderly patients: a narrative review.Korean journal of anesthesiology · 2026Review
- Windows to Consciousness: The Role of Fronto-Parietal Connectivity in Anesthesia-Induced Unconsciousness.Current neuropharmacology · 2026Review
- Neural Circuit Mechanisms of General Anaesthesia Induction: Current Advances and Future Directions.Current neuropharmacology · 2026Review
- High-precision neural information detection of multiple brain regions in mice under different concentrations of isoflurane anesthesia based on microelectrode arrays.Microsystems & nanoengineering · 2025Article
- Brain activity during intraoperative general anesthesia using resting-state functional magnetic resonance imaging ~ Feasibility study ~.Journal of anesthesia · 2025Article
- Connectome harmonic decomposition tracks the presence of disconnected consciousness during ketamine-induced unresponsiveness.British journal of anaesthesia · 2025Article
- Accurate Machine Learning-based Monitoring of Anesthesia Depth with EEG Recording.Neuroscience bulletin · 2025Article
- An essential role for the latero-medial secondary visual cortex in the acquisition and retention of visual perceptual learning in mice.Nature communications · 2024Article
- Separation of responsive and unresponsive patients under clinical conditions: comparison of symbolic transfer entropy and permutation entropy.Journal of clinical monitoring and computing · 2024Article
- Criticality supports cross-frequency cortical-thalamic information transfer during conscious states.eLife · 2024Article
- The nature of consciousness in anaesthesia.BJA open · 2023Review
- Information-theoretic analyses of neural data to minimize the effect of researchers' assumptions in predictive coding studies.PLoS computational biology · 2023Article
- An implementation of integrated information theory in resting-state fMRI.Communications biology · 2023Article
62 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe precise mechanism and optimal measure of anesthetic-induced unconsciousness has yet to be elucidated. Preferential inhibition of feedback connectivity from frontal to parietal brain networks is one potential neurophysiologic correlate, but has only been demonstrated in animals or under limited conditions in healthy volunteers. METHODS AND
findingsWe recruited eighteen patients presenting for surgery under general anesthesia; electroencephalography of the frontal and parietal regions was acquired during (i) baseline consciousness, (ii) anesthetic induction with propofol or sevoflurane, (iii) general anesthesia, (iv) recovery of consciousness, and (v) post-recovery states. We used two measures of effective connectivity, evolutional map approach and symbolic transfer entropy, to analyze causal interactions of the frontal and parietal regions. The dominant feedback connectivity of the baseline conscious state was inhibited after anesthetic induction and during general anesthesia, resulting in reduced asymmetry of feedback and feedforward connections in the frontoparietal network. Dominant feedback connectivity returned when patients recovered from anesthesia. Both analytic techniques and both classes of anesthetics demonstrated similar results in this heterogeneous population of surgical patients.
conclusionsThe disruption of dominant feedback connectivity in the frontoparietal network is a common neurophysiologic correlate of general anesthesia across two anesthetic classes and two analytic measures. This study represents a key translational step from the underlying cognitive neuroscience of consciousness to more sophisticated monitoring of anesthetic effects in human surgical patients.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.