ArticlePLoS genetics2011
Developmental stability: a major role for cyclin G in drosophila melanogaster.
Article in PLoS genetics, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
22 citing papers in PubMed, 54 citations in OpenAlex.
- Genome-wide screen for deficiencies modifying Cyclin G-induced developmental instability in Drosophila melanogaster.Genetics · 2026Article
- Article
- A Dilp8-dependent time window ensures tissue size adjustment in Drosophila.Nature communications · 2022Article
- Complex effects of environment and Wolbachia infections on the life history of Drosophila melanogaster hosts.Journal of evolutionary biology · 2022Article
- Article
- Precise Quantification of Behavioral Individuality From 80 Million Decisions Across 183,000 Flies.Frontiers in behavioral neuroscience · 2022Article
- Modulation of Yorkie activity by alternative splicing is required for developmental stability.The EMBO journal · 2021Article
- Extreme developmental instability associated with wing plasticity in pea aphids.Proceedings. Biological sciences · 2020Article
- Mouse Skull Mean Shape and Shape Robustness Rely on Different Genetic Architectures and Different Loci.Frontiers in genetics · 2019Article
- Systemic signalling and local effectors in developmental stability, body symmetry, and size.Cell stress · 2018Review
- Cyclin G and the Polycomb Repressive complexes PRC1 and PR-DUB cooperate for developmental stability.PLoS genetics · 2018Article
- Stochastic loss and gain of symmetric divisions in the C. elegans epidermis perturbs robustness of stem cell number.PLoS biology · 2017Article
- Fluctuating asymmetry of meristic traits: an isofemale line analysis in an invasive drosophilid, Zaprionus indianus.Genetica · 2017Article
- Little effect of HSP90 inhibition on the quantitative wing traits variation in Drosophila melanogaster.Genetica · 2017Article
- Modularity and developmental stability in segmented animals: variation in translational asymmetry in geophilomorph centipedes.Development genes and evolution · 2016Article
- Parallel effects of the inversion In(3R)Payne on body size across the North American and Australian clines in Drosophila melanogaster.Journal of evolutionary biology · 2016Article
- Pervasive robustness in biological systems.Nature reviews. Genetics · 2015Review
- Cyclin G Functions as a Positive Regulator of Growth and Metabolism in Drosophila.PLoS genetics · 2015Article
- Studying morphological integration and modularity at multiple levels: concepts and analysis.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2014Review
- Canalization and developmental instability of the fetal skull in a mouse model of maternal nutritional stress.American journal of physical anthropology · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 5 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Morphological consistency in metazoans is remarkable given the pervasive occurrence of genetic variation, environmental effects, and developmental noise. Developmental stability, the ability to reduce developmental noise, is a fundamental property of multicellular organisms, yet its genetic bases remains elusive. Imperfect bilateral symmetry, or fluctuating asymmetry, is commonly used to estimate developmental stability. We observed that Drosophila melanogaster overexpressing Cyclin G (CycG) exhibit wing asymmetry clearly detectable by sight. Quantification of wing size and shape using geometric morphometrics reveals that this asymmetry is a genuine-but extreme-fluctuating asymmetry. Overexpression of CycG indeed leads to a 40-fold increase of wing fluctuating asymmetry, which is an unprecedented effect, for any organ and in any animal model, either in wild populations or mutants. This asymmetry effect is not restricted to wings, since femur length is affected as well. Inactivating CycG by RNAi also induces fluctuating asymmetry but to a lesser extent. Investigating the cellular bases of the phenotypic effects of CycG deregulation, we found that misregulation of cell size is predominant in asymmetric flies. In particular, the tight negative correlation between cell size and cell number observed in wild-type flies is impaired when CycG is upregulated. Our results highlight the role of CycG in the control of developmental stability in D. melanogaster. Furthermore, they show that wing developmental stability is normally ensured via compensatory processes between cell growth and cell proliferation. We discuss the possible role of CycG as a hub in a genetic network that controls developmental stability.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.