SynthesisPLoS genetics2011
Identification, replication, and fine-mapping of Loci associated with adult height in individuals of african ancestry.
Synthesis in PLoS genetics, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 71 papers, 6 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
71 citing papers in PubMed, 6 syntheses or guidelines pooled it.
- Large meta-analysis of genome-wide association studies identifies five loci for lean body mass.Nature communications · 2017Pooled it
- Molecular genetic evidence for overlap between general cognitive ability and risk for schizophrenia: a report from the Cognitive Genomics consorTium (COGENT).Molecular psychiatry · 2014Pooled it
- Pooled it
- Replication and fine mapping of asthma-associated loci in individuals of African ancestry.Human genetics · 2013Pooled it
- A meta-analysis identifies new loci associated with body mass index in individuals of African ancestry.Nature genetics · 2013Pooled it
- Genome-wide association study of body height in African Americans: the Women's Health Initiative SNP Health Association Resource (SHARe).Human molecular genetics · 2012Pooled it
- Admixture mapping and fine-mapping of birth weight loci in the Black Women's Health Study.Human genetics · 2018Trial
- Barrett's esophagus-associated genetic loci in African Americans: a case-control study using the All of Us Research Program.European journal of gastroenterology & hepatology · 2026Observational
- Article
- Genome-wide association study reveals candidate loci on ECA1 and ECA9 for withers height in Friesian horses.Animal genetics · 2025Article
- Leveraging local ancestry and cross-ancestry genetic architecture to improve genetic prediction of complex traits in admixed populations.American journal of human genetics · 2025Article
- Novel homozygous SPAG17 variants cause human male infertility through multiple morphological abnormalities of spermatozoal flagella related to axonemal microtubule doublets.Asian journal of andrology · 2025Article
- Functional genomics of human skeletal development and the patterning of height heritability.Cell · 2025Article
- Association ofMolecular genetics and metabolism reports · 2024Article
- Elucidation of genetic determinants of dyslipidaemia using a global screening array for the early detection of coronary artery disease.Mammalian genome : official journal of the International Mammalian Genome Society · 2023Article
- Article
- Article
- Human height: a model common complex trait.Annals of human biology · 2023Review
- Reduced SPAG17 Expression in Systemic Sclerosis Triggers Myofibroblast Transition and Drives Fibrosis.The Journal of investigative dermatology · 2023Article
- Bench Research Informed by GWAS Results.Cells · 2021Review
11 more citing papers are in PubMed but not listed here.
Corrections and comments
- Erratum issued
Authors and funding
80 authors.
Funding
Abstract
Adult height is a classic polygenic trait of high heritability (h(2) approximately 0.8). More than 180 single nucleotide polymorphisms (SNPs), identified mostly in populations of European descent, are associated with height. These variants convey modest effects and explain approximately10% of the variance in height. Discovery efforts in other populations, while limited, have revealed loci for height not previously implicated in individuals of European ancestry. Here, we performed a meta-analysis of genome-wide association (GWA) results for adult height in 20,427 individuals of African ancestry with replication in up to 16,436 African Americans. We found two novel height loci (Xp22-rs12393627, P = 3.4×10(-12) and 2p14-rs4315565, P = 1.2×10(-8)). As a group, height associations discovered in European-ancestry samples replicate in individuals of African ancestry (P = 1.7×10(-4) for overall replication). Fine-mapping of the European height loci in African-ancestry individuals showed an enrichment of SNPs that are associated with expression of nearby genes when compared to the index European height SNPs (P<0.01). Our results highlight the utility of genetic studies in non-European populations to understand the etiology of complex human diseases and traits.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.