ArticleThe Journal of infectious diseases2011
Hemoglobin S and C heterozygosity enhances neither the magnitude nor breadth of antibody responses to a diverse array of Plasmodium falciparum antigens.
Article in The Journal of infectious diseases, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.
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Who cites it
28 citing papers in PubMed, 1 synthesis or guideline pooled it, 41 citations in OpenAlex.
- Haemoglobinopathies and the clinical epidemiology of malaria: a systematic review and meta-analysis.The Lancet. Infectious diseases · 2012Pooled it
- Elevated Plasmodium falciparum sexual conversion in HbAC and HbAS red blood cells in naturally infected malaria patients.PLoS pathogens · 2026Article
- Kinetics of antimalarial antibodies in children with common haemoglobinopathies in a Tanzanian population.Frontiers in immunology · 2026Article
- Cellular and molecular targets in β-Thalassemia: advances in iron Regulation, Erythropoiesis, and Gene-Based therapies.Functional & integrative genomics · 2025Review
- Children with hemoglobin C or S trait have low serologic responses to a subset of malaria variant surface antigens.The Journal of infection · 2024Article
- Profiling the Plasmodium falciparum Erythrocyte Membrane Protein 1-Specific Immununoglobulin G Response Among Ghanaian Children With Hemoglobin S and C.The Journal of infectious diseases · 2024Article
- PfEMP1-Specific Immunoglobulin G Reactivity Among Beninese Pregnant Women With Sickle Cell Trait.Open forum infectious diseases · 2021Article
- Memory CD8Clinical & translational immunology · 2021Article
- A novel population of memory-activated natural killer cells associated with low parasitaemia inClinical & translational immunology · 2020Article
- KILchip v1.0: A NovelFrontiers in immunology · 2018Article
- β-Thalassemia Distribution in the Old World: an Ancient Disease Seen from a Historical Standpoint.Mediterranean journal of hematology and infectious diseases · 2017Review
- Mining, visualizing and comparing multidimensional biomolecular data using the Genomics Data Miner (GMine) Web-Server.Scientific reports · 2016Article
- Stage-dependent fate of Plasmodium falciparum-infected red blood cells in the spleen and sickle-cell trait-related protection against malaria.Malaria journal · 2016Article
- Review
- A systems biology approach for diagnostic and vaccine antigen discovery in tropical infectious diseases.Current opinion in infectious diseases · 2015Review
- Genetic determinants of anti-malarial acquired immunity in a large multi-centre study.Malaria journal · 2015Article
- Submicroscopic and asymptomatic Plasmodium falciparum and Plasmodium vivax infections are common in western Thailand - molecular and serological evidence.Malaria journal · 2015Article
- Malaria parasites and red cell variants: when a house is not a home.Current opinion in hematology · 2014Review
- Biochemical and immunological mechanisms by which sickle cell trait protects against malaria.Malaria journal · 2013Review
- The genetic theory of infectious diseases: a brief history and selected illustrations.Annual review of genomics and human genetics · 2013Review
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Authors and funding
10 authors at 4 institutions in 2 countries.
Funding
Abstract
backgroundHeterozygous states of hemoglobin (Hb) A and HbS (HbAS, sickle-cell trait) or HbC (HbAC) protect against Plasmodium falciparum malaria by unclear mechanisms. Several studies suggest that HbAS and HbAC accelerate the acquisition of immunity to malaria, possibly by enhancing P. falciparum-specific antibody responses.
methodsWe used a protein microarray representing 491 P. falciparum proteins expressed during exoerythrocytic and erythrocytic stages of the life cycle to test the hypothesis that HbAS and HbAC enhance the P. falciparum-specific IgG response compared with normal HbAA. Plasma samples were collected from Malian children aged 2-10 years before and after a 6-month malaria season and were probed against the microarray. Immunoglobulin G (IgG) profiles of children with HbAA (n = 106), HbAS (n = 15), and HbAC (n = 20) were compared.
resultsAlthough the magnitude and breadth of P. falciparum-specific IgG responses increased with age and from before to after the malaria season in each antigen category, Hb type did not independently predict significant differences in P. falciparum-specific IgG profiles.
conclusionsThese data do not support the hypothesis that HbAS and HbAC protect against malaria by enhancing P. falciparum-specific antibody responses. It remains possible that HbAS and HbAC protect against malaria by enhancing antibody responses to antigens not studied here or through other immune mechanisms.
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Registered trials
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