ArticleJournal of immunology (Baltimore, Md. : 1950)2011
A disintegrin and metalloproteinase 10 regulates antibody production and maintenance of lymphoid architecture.
Article in Journal of immunology (Baltimore, Md. : 1950), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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Who cites it
22 citing papers in PubMed, 36 citations in OpenAlex.
- The ADAM Family of Proteases: Structure, Substrates, and Roles in Liver Diseases.International journal of molecular sciences · 2026Review
- Expression of ADAM10 and CD58 in Acute and Chronic Lymphocytic Leukemia: Influence of Disease Stage and Chemotherapy.Iranian journal of pathology · 2025Article
- ADAM10 is involved in the oncogenic process and chemo-resistance of triple-negative breast cancer via regulating Notch1 signaling pathway, CD44 and PrPc.Cancer cell international · 2021Article
- Article
- Amino acid starvation enhances vaccine efficacy by augmenting neutralizing antibody production.Science signaling · 2019Article
- Non-canonical B cell functions in transplantation.Human immunology · 2019Review
- B Cell ADAM10 Controls Murine Lupus Progression through Regulation of the ICOS:ICOS Ligand Axis.Journal of immunology (Baltimore, Md. : 1950) · 2019Article
- The emerging role of ADAM metalloproteinases in immunity.Nature reviews. Immunology · 2018Review
- Morphophysiological changes in the splenic extracellular matrix of Leishmania infantum-naturally infected dogs is associated with alterations in lymphoid niches and the CD4+ T cell frequency in spleens.PLoS neglected tropical diseases · 2018Article
- ADAM10 and Notch1 on murine dendritic cells control the development of type 2 immunity and IgE production.Allergy · 2018Article
- Regulation of Leukocytes by TspanC8 Tetraspanins and the "Molecular Scissor" ADAM10.Frontiers in immunology · 2018Review
- ADAM10-Mediated ICOS Ligand Shedding on B Cells Is Necessary for Proper T Cell ICOS Regulation and T Follicular Helper Responses.Journal of immunology (Baltimore, Md. : 1950) · 2017Article
- Impaired immunological synapse in sperm associated antigen 6 (SPAG6) deficient mice.Scientific reports · 2016Article
- ADAM Proteases and Gastrointestinal Function.Annual review of physiology · 2016Review
- Article
- ADAM10 is required for SCF-induced mast cell migration.Cellular immunology · 2014Article
- Tissue-specific patterning of host innate immune responses by Staphylococcus aureus α-toxin.Journal of innate immunity · 2014Article
- Disturbed follicular architecture in B cell A disintegrin and metalloproteinase (ADAM)10 knockouts is mediated by compensatory increases in ADAM17 and TNF-α shedding.Journal of immunology (Baltimore, Md. : 1950) · 2013Article
- Neuronal and nonneuronal cholinergic structures in the mouse gastrointestinal tract and spleen.The Journal of comparative neurology · 2013Article
- Fyn kinase is required for optimal humoral responses.PloS one · 2013Article
Corrections and comments
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Authors and funding
10 authors at 4 institutions in 2 countries.
Funding
Abstract
A disintegrin and metalloproteinase 10 (ADAM10) is a zinc-dependent proteinase related to matrix metalloproteinases. ADAM10 has emerged as a key regulator of cellular processes by cleaving and shedding extracellular domains of multiple transmembrane receptors and ligands. We have developed B cell-specific ADAM10-deficient mice (ADAM10(B-/-)). In this study, we show that ADAM10 levels are significantly enhanced on germinal center B cells. Moreover, ADAM10(B-/-) mice had severely diminished primary and secondary responses after T-dependent immunization. ADAM10(B-/-) displayed impaired germinal center formation, had fewer follicular Th cells, decreased follicular dendritic cell networks, and altered chemokine expression in draining lymph nodes (LNs). Interestingly, when spleen and LN structures from immunized mice were analyzed for B and T cell localization, tissues structure was aberrant in ADAM10(B-/-) mice. Importantly, when ADAM10-deficient B cells were stimulated in vitro, they produced comparable Ab as wild type B cells. This result demonstrates that the defects in humoral responses in vivo result from inadequate B cell activation, likely because of the decrease in follicular Th cells and the changes in structure. Thus, ADAM10 is essential for the maintenance of lymphoid structure after Ag challenge.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.