Evidence map›Paper›PMID 21998319›Full record

Trial reportNeurology2011

Transient ischemic attacks characterized by RNA profiles in blood.

X Zhan, G C Jickling, Y Tian, B Stamova, H Xu, B P Ander, R J Turner, M Mesias, P Verro, C Bushnell and 2 more

Registry-linked trialOpen access · bronzeAbstract readComparative StudyMulticenter StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Neurology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02014896 (Ischemia Care Biomarkers of Acute Stroke Etiology), which is not on this map. Cited by 14 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 1 pooled it
1.6field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02014896 completednot on this mapstarted 2013, after this paper: background citation

Ischemia Care Biomarkers of Acute Stroke Etiology (BASE)

TypeobservationalSponsorIschemia Care LLCRan2013 to 2020Enrolled1,750ConditionsIschemic Stroke, Atrial Fibrillation, Transient Ischemic Attacks, Transient Cerebrovascular EventsArmsBiomarker blood draw
3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 1 synthesis or guideline pooled it, 36 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Review
  5. Article
  6. Acute Stroke Biomarkers: Are We There Yet?Frontiers in neurology · 2021
    Review
  7. Review
  8. Review
  9. Circulating pro-angiogenic and anti-angiogenic microRNA expressions in patients with acute ischemic stroke and their association with disease severity.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2017
    Article
  10. Review
  11. Article
  12. Circulating microRNAs as biomarkers of acute stroke.International journal of molecular sciences · 2014
    Article
  13. Review
  14. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors at 1 institution in 1 country.

X ZhanDepartment of Neurology, MIND Institute Research Wet Labs-Room 2415, University of California at Davis, 2805 50 Street, Sacramento, CA 95817, USA. xzhan@ucdavis.edu
G C Jickling
Y Tian
B Stamova
H Xu
B P Ander
R J Turner
M Mesias
P Verro
C Bushnell
S C Johnston
F R Sharp
Wake Forest University · US

Funding

Ischemic Stroke and Intracerebral Hemorrhage Genomic Studies in HumansR01NS056302 · NINDS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI SHARP, FRANK R · 2007 to 2011
$3.0M
Sex Differences in Vascular Markers of Stroke RiskK02NS058760 · NINDS · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI BUSHNELL, CHERYL D · 2008 to 2012
$788k
NINDS NIH HHS K02 NS058760NINDS NIH HHS NS056302NINDS NIH HHS R01 NS056302
6 · The paper itself

Abstract

objectiveTransient ischemic attacks (TIA) are common. Though systemic inflammation and thrombosis are associated with TIA, further study may provide insight into TIA pathophysiology and possibly lead to the development of treatments specifically targeted to TIA. We sought to determine whether gene expression profiles in blood could better characterize the proinflammatory and procoagulant states in TIA patients.

methodsRNA expression in blood of TIA patients (n = 26) was compared to vascular risk factor control subjects without symptomatic cardiovascular disease (n = 26) using Affymetrix U133 Plus 2.0 microarrays. Differentially expressed genes in TIA were identified by analysis of covariance and evaluated with cross-validation and functional analyses.

resultsPatients with TIA had different patterns of gene expression compared to controls. There were 480 probe sets, corresponding to 449 genes, differentially expressed between TIA and controls (false discovery rate correction for multiple comparisons, p ≤ 0.05, absolute fold change ≥1.2). These genes were associated with systemic inflammation, platelet activation, and prothrombin activation. Hierarchical cluster analysis of the identified genes suggested the presence of 2 patterns of RNA expression in patients with TIA. Prediction analysis identified a set of 34 genes that discriminated TIA from controls with 100% sensitivity and 100% specificity.

conclusionPatients with recent TIA have differences of gene expression in blood compared to controls. The 2 gene expression profiles associated with TIA suggests heterogeneous responses between subjects with TIA that may provide insight into cause, risk of stroke, and other TIA pathophysiology.

Indexed as

Gene Expression ProfilingGene Expression RegulationAgedFemaleHumansIschemic Attack, TransientMaleMiddle AgedRisk FactorsRNARNA

Identifiers

PMID21998319
PMCPMC3208953
OpenAlexW2128049611

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.