ArticleJournal of applied physiology (Bethesda, Md. : 1985)2012
In situ enhancement of pulmonary surfactant function using temporary flow reversal.
Article in Journal of applied physiology (Bethesda, Md. : 1985), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 27 citations in OpenAlex.
- Microphysiological systems modeling acute respiratory distress syndrome that capture mechanical force-induced injury-inflammation-repair.APL bioengineering · 2019Review
- Surfactant Protein B Deficiency Induced High Surface Tension: Relationship between Alveolar Micromechanics, Alveolar Fluid Properties and Alveolar Epithelial Cell Injury.International journal of molecular sciences · 2019Article
- Effects of surfactant on propagation and rupture of a liquid plug in a tube.Journal of fluid mechanics · 2019Article
- Ventilator-induced lung injury and lung mechanics.Annals of translational medicine · 2018Review
- Linking lung function to structural damage of alveolar epithelium in ventilator-induced lung injury.Respiratory physiology & neurobiology · 2018Article
- Surfactant-induced Marangoni transport of lipids and therapeutics within the lung.Current opinion in colloid & interface science · 2018Article
- Linking Ventilator Injury-Induced Leak across the Blood-Gas Barrier to Derangements in Murine Lung Function.Frontiers in physiology · 2017Article
- Patterns of recruitment and injury in a heterogeneous airway network model.Journal of the Royal Society, Interface · 2015Article
- Computational Models of Ventilator Induced Lung Injury and Surfactant Dysfunction.Drug discovery today. Disease models · 2015Article
- Surface tension in situ in flooded alveolus unaltered by albumin.Journal of applied physiology (Bethesda, Md. : 1985) · 2014Article
- Acute chlorine gas exposure produces transient inflammation and a progressive alteration in surfactant composition with accompanying mechanical dysfunction.Toxicology and applied pharmacology · 2014Article
- The unusual symmetric reopening effect induced by pulmonary surfactant.Journal of applied physiology (Bethesda, Md. : 1985) · 2014Article
- Atelectrauma disrupts pulmonary epithelial barrier integrity and alters the distribution of tight junction proteins ZO-1 and claudin 4.Journal of applied physiology (Bethesda, Md. : 1985) · 2012Article
- Interfacial stress affects rat alveolar type II cell signaling and gene expression.American journal of physiology. Lung cellular and molecular physiology · 2012Article
- The influence of surfactant on the propagation of a semi-infinite bubble through a liquid-filled compliant channel.Journal of fluid mechanics · 2012Article
- Lagrangian transport properties of pulmonary interfacial flows.Journal of fluid mechanics · 2011Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Acute respiratory distress syndrome is a pulmonary disease with a mortality rate of ∼40% and 75,000 deaths annually in the United States. Mechanical ventilation restores airway patency and gas transport but leads to ventilator-induced lung injury. Furthermore, surfactant replacement therapy is ineffective due to surfactant delivery difficulties and deactivation by vascular proteins leaking into the airspace. Here, we demonstrated that surfactant function can be substantially improved (up to 50%) in situ in an in vitro pulmonary airway model using unconventional flows that incorporate a short-term retraction of the air-liquid interface, leading to a net decrease in cellular damage. Computational fluid dynamic simulations provided insights into this method and demonstrated the physicochemical hydrodynamic foundation for the improved surfactant microscale transport and mobility. This study may provide a starting point for developing novel ventilation waveforms to improve surfactant function in edematous airways.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.