ArticleMolecular biology of the cell2011
Defining pheromone-receptor signaling in Candida albicans and related asexual Candida species.
Article in Molecular biology of the cell, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 12 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
12 citing papers in PubMed, 19 citations in OpenAlex.
- Is There a Relationship Between Mating and Pathogenesis in Two Human Fungal Pathogens,Current clinical microbiology reports · 2023Review
- Non-antifungal drugs inhibit growth, morphogenesis and biofilm formation in Candida albicans.The Journal of antibiotics · 2021Article
- Unraveling HowJournal of fungi (Basel, Switzerland) · 2020Review
- In Vitro Culturing and Screening of Candida albicans Biofilms.Current protocols in microbiology · 2018Article
- New approaches in bioprocess-control: Consortium guidance by synthetic cell-cell communication based on fungal pheromones.Engineering in life sciences · 2018Review
- Structure-Activity Relationship of α Mating Pheromone from the Fungal PathogenThe Journal of biological chemistry · 2017Article
- Phenotypic Plasticity Regulates Candida albicans Interactions and Virulence in the Vertebrate Host.Frontiers in microbiology · 2016Article
- A novel function for Hog1 stress-activated protein kinase in controlling white-opaque switching and mating in Candida albicans.Eukaryotic cell · 2014Article
- Sexual biofilm formation in Candida tropicalis opaque cells.Molecular microbiology · 2014Article
- Article
- Passage through the mammalian gut triggers a phenotypic switch that promotes Candida albicans commensalism.Nature genetics · 2013Article
- Genetic control of conventional and pheromone-stimulated biofilm formation in Candida albicans.PLoS pathogens · 2013Article
Corrections and comments
- Erratum issued
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Candida albicans is an important human fungal pathogen in which sexual reproduction is under the control of the novel white-opaque switch. Opaque cells are the mating-competent form, whereas white cells do not mate but can still respond to pheromones, resulting in biofilm formation. In this study, we first define the domains of the α-pheromone receptor Ste2 that are necessary for signaling in both white and opaque forms. Both cell states require the IC loop 3 (IC3) and the C-terminal tail of Ste2 for the cellular response, whereas the first IC loop (IC1) of Ste2 is dispensable for signaling. To also address pheromone-receptor interactions in related species, including apparently asexual Candida species, Ste2 orthologues were heterologously expressed in Candida albicans. Ste2 receptors from multiple Candida clade species were functional when expressed in C. albicans, whereas the Ste2 receptor of Candida lusitaniae was nonfunctional. Significantly, however, expression of a chimeric C. lusitaniae Ste2 receptor containing the C-terminal tail of Ste2 from C. albicans generated a productive response to C. lusitaniae pheromone. This system has allowed us to characterize pheromones from multiple Candida species and indicates that functional pheromone-receptor couples exist in fungal species that have yet to be shown to undergo sexual mating.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.