ArticleMicrobiology (Reading, England)2012
The two-component QseBC signalling system regulates in vitro and in vivo virulence of Aeromonas hydrophila.
Article in Microbiology (Reading, England), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
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Who cites it
38 citing papers in PubMed, 74 citations in OpenAlex.
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- The CitAB two-component system is involved in pathogenesis regulation in Avian pathogenic3 Biotech · 2025Article
- Regulation of type 3 fimbria expression by RstA affects biofilm formation and virulence inMicrobiology spectrum · 2025Article
- OxyR contributes to the oxidative stress capacity and virulence of hypervirulentFrontiers in cellular and infection microbiology · 2025Article
- Lonicera japonica protects Pelodiscus sinensis by inhibiting the biofilm formation of Aeromonas hydrophila.Applied microbiology and biotechnology · 2024Article
- Antimicrobial resistance in aeromonads and new therapies targeting quorum sensing.Applied microbiology and biotechnology · 2024Review
- Carvacrol Inhibits Quorum Sensing in Opportunistic BacteriumMicroorganisms · 2023Article
- In Vitro Antibiofilm Activity of Resveratrol againstAntibiotics (Basel, Switzerland) · 2023Article
- The Role of the Two-Component QseBC Signaling System in Biofilm Formation and Virulence of HypervirulentFrontiers in microbiology · 2022Article
- Comparative and Evolutionary Genomics of Isolates Provide Insight into the Pathoadaptation of Aeromonas.Genome biology and evolution · 2020Article
- Effect of curcumin on the expression of ahyI/R quorum sensing genes and some associated phenotypes in pathogenic Aeromonas hydrophila fish isolates.World journal of microbiology & biotechnology · 2020Article
- QseC Inhibition as a Novel Antivirulence Strategy for the Prevention of Acute Hepatopancreatic Necrosis Disease (AHPND)-CausingFrontiers in cellular and infection microbiology · 2020Article
- Article
- Diverse effects of nitric oxide reductase NorV on Aeromonas hydrophila virulence-associated traits under aerobic and anaerobic conditions.Veterinary research · 2019Article
- QseC Signaling in the Outbreak O104:H4Journal of bacteriology · 2019Article
- Discovery ofInternational journal of molecular sciences · 2018Article
- Novel Role of VisP and the Wzz System during O-Antigen Assembly in Salmonella enterica Serovar Typhimurium Pathogenesis.Infection and immunity · 2018Article
- A two-component signal transduction system contributes to the virulence ofJournal of veterinary science · 2018Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
We recently demonstrated that the N-acyl-homoserine lactone [autoinducer (AI)-1] and LuxS (AI-2)-based quorum-sensing (QS) systems exerted positive and negative regulation, respectively, on the virulence of a diarrhoeal isolate SSU of Aeromonas hydrophila. However, the role of a newly identified, two-component-based QseBC QS system in the regulation of bacterial virulence in general is not well understood, with only a limited number of studies showing its function in bacterial pathogenesis. In this report, we identified and characterized the QseBC QS system in A. hydrophila SSU and found that, as was the case with enterohaemorrhagic Escherichia coli, the open reading frames for the qseB (the response regulator) and qseC (the sensor histidine kinase) genes overlapped by 4 bp at the ATGA motif. Our data provide evidence that deletion of the qseB gene from A. hydrophila resulted in attenuation of bacterial virulence in a septicaemic mouse model of infection and diminished swimming and swarming motility, and the mutant bacteria formed denser biofilms compared with those from the parental strain of A. hydrophila. The decrease in the virulence of the A. hydrophila ΔqseB mutant correlated with reduced production of protease and the cytotoxic enterotoxin, which has associated haemolytic activity. The swimming and swarming motility, haemolytic activity, protease production and biofilm formation were restored in the qseBC-complemented strain to a level similar to that of the wild-type A. hydrophila SSU. Our study is the first, to our knowledge, to report a functional QseBC QS system in A. hydrophila which may be linked to AI-1 and AI-2 QS systems in modulating bacterial virulence, possibly through the cyclic diguanosine monophosphate.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.