ArticleStem cells (Dayton, Ohio)2011
Fibroblast growth factor regulates human neuroectoderm specification through ERK1/2-PARP-1 pathway.
Article in Stem cells (Dayton, Ohio), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 40 citations in OpenAlex.
- Article
- The role of homeobox genes in signaling pathway positive feedback loops and cancer therapy.Frontiers in oncology · 2026Article
- MeCP2 dysfunction prevents proper BMP signaling and neural progenitor expansion in brain organoid.Annals of clinical and translational neurology · 2023Article
- Supporting data on combined transcriptomic and phosphoproteomic analysis of BMP4 signaling in human embryonic stem cells.Data in brief · 2021Article
- Poly (ADP-Ribose) Polymerase 1 Regulates Cajal-Retzius Cell Development and Neural Precursor Cell Adhesion.Frontiers in cell and developmental biology · 2021Article
- Kinetic modeling of stem cell transcriptome dynamics to identify regulatory modules of normal and disturbed neuroectodermal differentiation.Nucleic acids research · 2020Article
- Accelerated differentiation of human pluripotent stem cells into neural lineages via an early intermediate ectoderm population.Stem cells (Dayton, Ohio) · 2020Article
- Modeling Mammalian Commitment to the Neural Lineage Using Embryos and Embryonic Stem Cells.Frontiers in physiology · 2019Review
- PKN2 in colon cancer cells inhibits M2 phenotype polarization of tumor-associated macrophages via regulating DUSP6-Erk1/2 pathway.Molecular cancer · 2018Article
- Transcriptome analysis reveals determinant stages controlling human embryonic stem cell commitment to neuronal cells.The Journal of biological chemistry · 2017Article
- Dysregulation of the SIRT1/OCT6 Axis Contributes to Environmental Stress-Induced Neural Induction Defects.Stem cell reports · 2017Article
- Catalytic-Independent Functions of PARP-1 Determine Sox2 Pioneer Activity at Intractable Genomic Loci.Molecular cell · 2017Article
- Cell-Cell Connection Enhances Proliferation and Neuronal Differentiation of Rat Embryonic Neural Stem/Progenitor Cells.Frontiers in cellular neuroscience · 2017Article
- Neural Subtype Specification from Human Pluripotent Stem Cells.Cell stem cell · 2016Review
- The cellular and molecular mechanisms of vertebrate lens development.Development (Cambridge, England) · 2014Review
- From pluripotency to forebrain patterning: an in vitro journey astride embryonic stem cells.Cellular and molecular life sciences : CMLS · 2014Review
- Neural induction and early patterning in vertebrates.Wiley interdisciplinary reviews. Developmental biology · 2013Review
- miR-200 and miR-96 families repress neural induction from human embryonic stem cells.Development (Cambridge, England) · 2013Article
- Epiblast ground state is controlled by canonical Wnt/β-catenin signaling in the postimplantation mouse embryo and epiblast stem cells.PloS one · 2013Article
- On PAR with PARP: cellular stress signaling through poly(ADP-ribose) and PARP-1.Genes & development · 2012Review
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Fibroblast growth factor (FGF) signaling and PAX6 transcription are required for neuroectoderm specification of human embryonic stem cells (hESCs). In this study, we asked how FGF signaling leads to PAX6 transcription and neuroectoderm specification from hESCs. Under a chemically defined medium, FGF inhibition blocked phosphorylation of extracellular signal-regulated kinase 1/2 (ERK 1/2) with a significant reduction of PAX6-expressing neuroepithelia, indicating that FGF regulates neural induction through ERK1/2 activation. Activation of FGF-ERK1/2 pathway was necessary for the activity of poly(ADP-ribose) polymerase-1 (PARP-1), a conserved nuclear protein catalyzing polymerization of ADP-ribose units. Pharmacological inhibition and genetic ablation of PARP-1 inhibited neural induction from hESCs, suggesting that FGF-ERK1/2 signal pathway regulates neuroectoderm specification through regulating PARP-1 activity. Furthermore, FGF-ERK1/2-PARP-1 cascade regulated the expression of PAX6, a transcription determinant of human neuroectoderm. Together, we propose that FGF regulates hESC neural specification through the ERK1/2-PARP-1 signaling pathway.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.