ArticleIndian journal of pediatrics2012
Risk factors and predictors of mortality in culture proven neonatal sepsis.
Article in Indian journal of pediatrics, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 2 of them syntheses that pooled it.
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Who cites it
13 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Prognosis of neonates receiving invasive mechanical ventilation in low-resource settings: a systematic review and prognostic meta-analysis.European journal of pediatrics · 2026Pooled it
- Contemporary Trends in Global Mortality of Sepsis Among Young Infants Less Than 90 Days: A Systematic Review and Meta-Analysis.Frontiers in pediatrics · 2022Pooled it
- Predictors of death in infants with probable serious bacterial infection.Pediatric research · 2018Trial
- Risk factors for community-acquired bacterial infection among young infants in South Asia: a longitudinal cohort study with nested case-control analysis.BMJ global health · 2022Article
- Identification of potential risk factors for the poor prognosis of neonatal sepsis.Medicine and pharmacy reports · 2022Article
- Extended Infusion of Meropenem in Neonatal Sepsis: A Historical Cohort Study.Antibiotics (Basel, Switzerland) · 2022Article
- Article
- Clinical and Bacteriological Profile of Neonatal Sepsis: A Prospective Hospital-Based Study.International journal of pediatrics · 2020Article
- Surveillance for incidence and etiology of early-onset neonatal sepsis in Soweto, South Africa.PloS one · 2019Article
- Management of Shock in Neonates.Indian journal of pediatrics · 2015Review
- Clinical and laboratory factors that predict death in very low birth weight infants presenting with late-onset sepsis.The Pediatric infectious disease journal · 2014Article
- Bacterial bloodstream infections in neonates in a developing country.ISRN pediatrics · 2012Article
- Risk factors for laboratory-confirmed bloodstream infection in neonates undergoing surgical procedures.The Brazilian journal of infectious diseases : an official publication of the Brazilian Society of Infectious DiseasesArticle
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Authors and funding
5 authors.
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Abstract
objectiveTo determine the risk factors associated with culture-proven neonatal sepsis and identify predictors of mortality among them.
methodsThis prospective observational study was conducted in a tertiary care teaching hospital in South India over a period of 2 y. All admitted inborn and out born neonates with clinically suspected sepsis were included in the study. Blood culture was done for all neonates. Various factors associated with sepsis and mortality were identified. Chi-square test or Fisher's exact test was used to compare two groups. The results of these tests were confirmed with logistic regression analysis.
resultsOf the 120 neonates, only 50 (41.6%) had a positive blood culture. Premature rupture of membranes (PROM) >24 h, Apgar score <6 at 5 min, birth weight ≤1.5 kg and mechanical ventilation were found to be the independent risk factors for culture-proven sepsis based on logistic regression analysis. Twenty-one (42%) of the 50 neonates with culture-proven sepsis died, while only 15 (21.4%) of the 70 neonates who were blood culture negative died (Relative risk, 1.69; 95% confidence interval, 1.13 to 2.53; P value 0.0263). Birth weight ≤1.5 kg, shock and lethargy were proved to be independent predictors of mortality.
conclusionsThe mortality rate was significantly high in neonates with a culture-proven sepsis compared to those with a negative blood culture. PROM >24 h, Apgar score <6 at 5 min, birth weight ≤1.5 kg and mechanical ventilation were independent risk factors for culture-proven sepsis, while lethargy, shock and birth weight ≤1.5 kg were independent predictors of mortality.
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