ArticleMolecular and cellular biochemistry2012
The effect of sevoflurane on the expression of M1 acetylcholine receptor in the hippocampus and cognitive function of aged rats.
Article in Molecular and cellular biochemistry, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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12 citing papers in PubMed, 30 citations in OpenAlex.
- Gyosaponin ameliorates sevoflurane anesthesia-induced cognitive dysfunction and neuronal apoptosis in rats through modulation of the PI3K/AKT/mTOR pathway.Clinics (Sao Paulo, Brazil) · 2025Article
- Role of gut microbiota in neuroinflammation: a focus on perioperative neurocognitive disorders.Frontiers in cellular and infection microbiology · 2025Review
- Targeting neuroinflammation as a preventive and therapeutic approach for perioperative neurocognitive disorders.Journal of neuroinflammation · 2022Review
- Effects of General Anesthetics on Synaptic Transmission and Plasticity.Current neuropharmacology · 2022Review
- Update on the Mechanism and Treatment of Sevoflurane-Induced Postoperative Cognitive Dysfunction.Frontiers in aging neuroscience · 2021Review
- Methylene Blue Protects Against Sevoflurane-Induced Cognitive Dysfunction by Suppressing Drp1 deSUMOylation in Aged Mice.Neurochemical research · 2020Article
- Sevoflurane anesthesia alters cognitive function by activating inflammation and cell death in rats.Experimental and therapeutic medicine · 2018Article
- Sevoflurane Exacerbates Cognitive Impairment Induced by AMediators of inflammation · 2018Article
- Grape Seed Proanthocyanidin and Swimming Exercise Protects Against Cognitive Decline: A Study on M1 Acetylcholine Receptors in Aging Male Rat Brain.Neurochemical research · 2017Article
- Insecticide imidacloprid influences cognitive functions and alters learning performance and related gene expression in a rat model.International journal of experimental pathology · 2015Article
- The inflammatory response of two different kinds of anesthetics on vascular cognitive impairment rats and the effect on long term cognitive function.International journal of clinical and experimental medicine · 2015Article
- Isoflurane reversibly destabilizes hippocampal dendritic spines by an actin-dependent mechanism.PloS one · 2014Article
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Our aim is to investigate the effect of 1.5 and 3.0% sevoflurane on the expression of M(1) acetylcholine receptor (mAChR M(1)) in the hippocampus and the cognitive function of aged rats. Forty Sprague-Dawley (SD) rats of 12-month old were randomly divided into five groups. All SD rats received 1.5 or 3.0% sevoflurane in a special glass anesthesia box for 2 h, respectively, except for the normal control group. Y-maze was used to test the ability of learning and memory after being received sevoflurane for 1 or 7 days at the same moment portion. The expression of mAChR M(1) in the hippocampus of rats was tested by RT-PCR. The results showed that 3% sevoflurane induced the decline of cognitive function and significantly decreased the mAChR M(1) expression at mRNA levels at 1 day in the 3.0% sevoflurane I group when compared with the normal control group. However, there was no significant difference among the other groups when compared with normal control group. Therefore, administration of sevoflurane might temporally affect the ability of cognitive function of rats through suppressing the mAChR M(1) expression at mRNA levels in hippocampus.
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