ArticleElectrophoresis2011
Translocation of single-stranded DNA through the α-hemolysin protein nanopore in acidic solutions.
Article in Electrophoresis, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed.
- Bioinformatic and computational biophysics tools for nanopore engineering: a review from standard approaches to machine learning advancements.Journal of nanobiotechnology · 2026Review
- Nanopore-Based, Real-Time Single-Molecule Probing of i-Motif Structural Dynamics and Targeted PNA Disruption.Nano letters · 2026Article
- Vectorial Discrimination of Small Molecules with a Macrocycle Adaptor-Protein Nanopore System and Nanocavity-Dependent, pH Gradient-Controlled Analyte Kinetics.Analytical chemistry · 2025Article
- Article
- Controlling DNA Fragments Translocation across Nanopores with the Synergic Use of Site-Directed Mutagenesis, pH-Dependent Charge Tuning, and Electroosmotic Flow.ACS applied materials & interfaces · 2024Article
- Probe-assisted detection of FeBiosensors & bioelectronics · 2024Article
- Nanopore sensing: A physical-chemical approach.Biochimica et biophysica acta. Biomembranes · 2021Review
- Nanopore detection of metal ions: Current status and future directions.Small methods · 2020Article
- Computation-Assisted Nanopore Detection of Thorium Ions.Analytical chemistry · 2018Article
- Nanopore Analysis of the 5-Guanidinohydantoin to Iminoallantoin Isomerization in Duplex DNA.The Journal of organic chemistry · 2018Article
- Remote Activation of a Nanopore for High-Performance Genetic Detection Using a pH Taxis-Mimicking Mechanism.Analytical chemistry · 2017Article
- Peptide-Mediated Nanopore Detection of Uranyl Ions in Aqueous Media.ACS sensors · 2017Article
- Revealing different aggregational states of a conjugated polymer in solution by a nanopore sensor.Chemical science · 2016Article
- Single molecule detection with graphene and other two-dimensional materials: nanopores and beyond.Chemical Society reviews · 2016Review
- Nanopore back titration analysis of dipicolinic acid.Electrophoresis · 2015Article
- Nanopore detection of copper ions using a polyhistidine probe.Biosensors & bioelectronics · 2014Article
- Detecting a single molecule using a micropore-nanopore hybrid chip.Nanoscale research letters · 2013Article
- Tuning the size and properties of ClyA nanopores assisted by directed evolution.Journal of the American Chemical Society · 2013Article
- Translocating kilobase RNA through the Staphylococcal α-hemolysin nanopore.Nano letters · 2013Article
- Electrical Current Signatures of DNA Base Modifications in Single Molecules Immobilized in the α-Hemolysin Ion Channel.Israel journal of chemistry · 2013Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
The effect of acidic pH on the translocation of single-stranded DNA through the α-hemolysin pore is investigated. Two significantly different types of events, i.e. deep blockades and shallow blockades, are observed at low pH. The residence times of the shallow blockades are not significantly different from those of the DNA translocation events obtained at or near physiological pH, whereas the deep blockades have much larger residence times and blockage amplitudes. With a decrease in the pH of the electrolyte solution, the percentage of the deep blockades in the total events increases. Furthermore, the mean residence time of these long-lived events is dependent on the length of DNA, and also varies with the nucleotide base, suggesting that they are appropriate for use in DNA analysis. In addition to being used as an effective approach to affect DNA translocation in the nanopore, manipulation of the pH of the electrolyte solution provides a potential means to greatly enhance the sensitivity of nanopore stochastic sensing.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.