ArticleInternational urology and nephrology2012
Total parathyroidectomy without autotransplantation after renal transplantation for tertiary hyperparathyroidism: long-term follow-up.
Article in International urology and nephrology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 34 citations in OpenAlex.
- Case report: Prolonged and severe hungry bone syndrome after parathyroidectomy in X-linked hypophosphatemia.Frontiers in endocrinology · 2024Article
- Surgical treatment of tertiary hyperparathyroidism: does one fit for all?Frontiers in endocrinology · 2023Article
- Management and outcomes of hyperparathyroidism: a case series from a single institution over two decades.Therapeutics and clinical risk management · 2018Article
- Surgical management of secondary hyperparathyroidism in chronic kidney disease--a consensus report of the European Society of Endocrine Surgeons.Langenbeck's archives of surgery · 2015Review
- Parathyroidectomy and patient survival in CKD patients.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2015Article
- Survival after parathyroidectomy in chronic hemodialysis patients with severe secondary hyperparathyroidism.International urology and nephrology · 2015Article
- Autotransplantation of parathyroid grafts into the tibialis anterior muscle after parathyroidectomy: a novel autotransplantation site.BMC surgery · 2015Article
- Total parathyroidectomy with autotransplantation for a rare disease derived from uremic secondary hyperparathyroidism, the uremic leontiasis ossea.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2014Article
- Current trends in surgery for renal hyperparathyroidism (RHPT)--an international survey.Langenbeck's archives of surgery · 2013Article
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionRenal transplant patients are unique in that bone changes occur on a background of pre-existing chronic kidney disease-mineral bone disorder. In a few cases, there is overt hyperparathyroidism manifested by hypercalcaemia. Traditionally, if severe or persistent, this is treated by parathyroidectomy. At our unit, the default surgical operation is total parathyroidectomy without autotransplantation.
methodsPatient charts for the last three decades were reviewed retrospectively. Twenty-six subjects with functioning renal transplants who underwent parathyroidectomy had biochemistry and clinical information for at least 6 months pre- and post-surgery. The criteria for parathyroidectomy were persistent hypercalcaemia (>2.75 mmol/L) and/or clinical problems (e.g. kidney stones). A 5-year follow-up was available for all 26 subjects and a 9-year follow-up for 20 patients.
resultsAfter surgery, patients were supplemented with 1-α-calcidol. The median preoperative calcium level was 3.10 mmol/L. One month postoperatively, this fell to 2.41 mmol/L. Normocalcaemia was maintained at 5 years (2.40 mmol/L) and at 9 years (2.39 mmol/L), with a calcium-phosphate product of 3.0 mmol(2)/L(2) and median parathyroid hormone level of 12 pg/mL.
conclusionTotal parathyroidectomy without autotransplantation in renal transplant patients appears to be protective against persistent and recurrent disease. This is the largest series with the longest follow-up available in the literature of this specific patient population.
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