ArticleCell death and differentiation2012
FGF2 regulates melanocytes viability through the STAT3-transactivated PAX3 transcription.
Article in Cell death and differentiation, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 42 citations in OpenAlex.
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- Genomic insights into population structure, genetic diversity, and key traits of Jiangxi indigenous pigs.BMC genomics · 2025Article
- Characterization of terpene extract from Cannabis sativa flower and evaluation of its anti-melanogenetic effect in melan-a cells.Scientific reports · 2025Article
- Sage extract and ascorbic acid derivative inhibit melanogenesis via downregulating keratinocyte-derived GM-CSF.PloS one · 2025Article
- Single-cell sequencing reveals increased LAMB3-positive basal keratinocytes and ZNF90-positive fibroblasts in autologous cultured epithelium.Communications biology · 2024Article
- Efficient prioritization of CRISPR screen hits by accounting for targeting efficiency of guide RNA.BMC biology · 2023Article
- Biology of melanocytes in mammals.Frontiers in cell and developmental biology · 2023Review
- Novel role of microphthalmia-associated transcription factor in modulating the differentiation and immunosuppressive functions of myeloid-derived suppressor cells.Journal for immunotherapy of cancer · 2023Article
- The influence of fibroblast growth factor 2 on the senescence of human adipose-derived mesenchymal stem cells during long-term culture.Stem cells translational medicine · 2020Article
- 3,4,5-Tri-Frontiers in cell and developmental biology · 2020Article
- Differentiation of adipose-derived stem cells to functional CD105Stem cell research & therapy · 2019Article
- Inhibitory effects of ginsenosides on basic fibroblast growth factor-induced melanocyte proliferation.Journal of ginseng research · 2017Article
- FOXD3 Promotes PAX3 Expression in Melanoma Cells.Journal of cellular biochemistry · 2016Article
- Expression of signal transducer and activator of transcription 3 and its phosphorylated form is significantly upregulated in patients with papillary thyroid cancer.Experimental and therapeutic medicine · 2015Article
- Immune Homeostasis in Epithelial Cells: Evidence and Role of Inflammasome Signaling Reviewed.Journal of immunology research · 2015Review
- Article
- MITF and PAX3 Play Distinct Roles in Melanoma Cell Migration; Outline of a "Genetic Switch" Theory Involving MITF and PAX3 in Proliferative and Invasive Phenotypes of Melanoma.Frontiers in oncology · 2013Review
- A STATement on vemurafenib-resistant melanoma.The Journal of investigative dermatology · 2013Article
- Stat3-targeted therapies overcome the acquired resistance to vemurafenib in melanomas.The Journal of investigative dermatology · 2013Article
Corrections and comments
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Authors and funding
10 authors at 4 institutions in 2 countries.
Funding
Abstract
PAX3 (paired box 3) is known to have an important role in melanocyte development through modulation of microphthalmia-associated transcription factor transcription. Here we found that PAX3 transcriptional activity could be regulated through FGF2 (basic fibroblast growth factor)-STAT3 (signal transducer and activator of transcription 3) signaling in the pigment cells. To study its function in vivo, we have generated a transgenic mouse model expressing PAX3 driven by tyrosinase promoter in a tissue-specific fashion. These animals exhibit hyperpigmentation in the epidermis, evident in the skin color of their ears and tails. We showed that the darker skin color results from both increased melanocyte numbers and melanin synthesis. Together, our study delineated a novel pathway in the melanocyte lineage, linking FGF2-STAT3 signaling to increased PAX3 transcription. Moreover, our results suggest that this pathway might contribute to the regulation of melanocyte numbers and melanin levels, and thereby provide an alternative strategy to induce pigmentation.
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Registered trials
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